INPP5B

Inositol polyphosphate-5-phosphatase B
Rendering based on PDB 3MTC​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3MTC​, 3N9V​, 4CML​
Identifiers
Symbols	INPP5B ; 5PTase
External IDs	OMIM: 147264 MGI: 103257 HomoloGene: 69021 ChEMBL: 2636 GeneCards: INPP5B Gene
EC number	3.1.3.36
Gene ontology Molecular function • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity • protein binding • metal ion binding • inositol-1,4,5-trisphosphate 5-phosphatase activity Cellular component • cytoplasm • endoplasmic reticulum-Golgi intermediate compartment • Golgi apparatus • cytosol • plasma membrane • membrane • integral component of membrane • phagocytic vesicle membrane • early endosome membrane Biological process • in utero embryonic development • protein dephosphorylation • small GTPase mediated signal transduction • spermatogenesis • sperm motility • inositol phosphate metabolic process • small molecule metabolic process • phosphatidylinositol dephosphorylation • regulation of small GTPase mediated signal transduction • regulation of protein processing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3633	16330
Ensembl	ENSG00000204084	ENSMUSG00000028894
UniProt	P32019	Q8K337
RefSeq (mRNA)	NM_001297434	NM_008385
RefSeq (protein)	NP_001284363	NP_032411
Location (UCSC)	Chr 1: 37.86 – 37.95 Mb	Chr 4: 124.74 – 124.8 Mb
PubMed search

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.^[1][2]

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[2]

References

1. Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem 266 (30): 20283–9. PMID 1718960.
2. "Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa".

Further reading

• Mitchell CA, Connolly TM, Majerus PW (1989). "Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets.". J. Biol. Chem. 264 (15): 8873–7. PMID 2542294.
• Jefferson AB, Majerus PW (1995). "Properties of type II inositol polyphosphate 5-phosphatase.". J. Biol. Chem. 270 (16): 9370–7. doi:10.1074/jbc.270.16.9370. PMID 7721860.
• Jänne PA, Dutra AS, Dracopoli NC, et al. (1994). "Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34.". Cytogenet. Cell Genet. 66 (3): 164–6. doi:10.1159/000133691. PMID 8125013.
• Speed CJ, Matzaris M, Bird PI, Mitchell CA (1996). "Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase.". Eur. J. Biochem. 234 (1): 216–24. doi:10.1111/j.1432-1033.1995.216_c.x. PMID 8529643.
• Jänne PA, Rochelle JM, Martin-DeLeon PA, et al. (1996). "Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens.". Genomics 28 (2): 280–5. doi:10.1006/geno.1995.1142. PMID 8530037.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.