INPPL1

Inositol polyphosphate phosphatase-like 1

Rendering based on PDB 2K4P.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols INPPL1 ; OPSMD; SHIP2
External IDs OMIM: 600829 MGI: 1333787 HomoloGene: 1204 GeneCards: INPPL1 Gene
EC number 3.1.3.86
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3636 16332
Ensembl ENSG00000165458 ENSMUSG00000032737
UniProt O15357 Q6P549
RefSeq (mRNA) NM_001567 NM_001122739
RefSeq (protein) NP_001558 NP_001116211
Location (UCSC) Chr 11:
72.22 – 72.24 Mb
Chr 7:
101.82 – 101.84 Mb
PubMed search

SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.[1][2]

INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.[2]

Interactions

INPPL1 has been shown to interact with:

References

  1. Hejna JA, Saito H, Merkens LS, Tittle TV, Jakobs PM, Whitney MA, Grompe M, Friedberg AS, Moses RE (February 1996). "Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases". Genomics 29 (1): 285–7. doi:10.1006/geno.1995.1247. PMID 8530088.
  2. 1 2 "Entrez Gene: INPPL1 inositol polyphosphate phosphatase-like 1".
  3. Prasad N, Topping RS, Decker SJ (February 2001). "SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading". Mol. Cell. Biol. 21 (4): 1416–28. doi:10.1128/MCB.21.4.1416-1428.2001. PMC 99593. PMID 11158326.
  4. Dyson JM, O'Malley CJ, Becanovic J, Munday AD, Berndt MC, Coghill ID, Nandurkar HH, Ooms LM, Mitchell CA (December 2001). "The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin". J. Cell Biol. 155 (6): 1065–79. doi:10.1083/jcb.200104005. PMC 2150887. PMID 11739414.
  5. Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B (April 1999). "A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells". Blood 93 (8): 2707–20. PMID 10194451.
  6. Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C (July 2001). "The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells". J. Biol. Chem. 276 (30): 28348–55. doi:10.1074/jbc.M103537200. PMID 11349134.
  7. Habib T, Hejna JA, Moses RE, Decker SJ (July 1998). "Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein". J. Biol. Chem. 273 (29): 18605–9. doi:10.1074/jbc.273.29.18605. PMID 9660833.
  8. Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I (January 2003). "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2". Biochem. Biophys. Res. Commun. 300 (2): 494–500. doi:10.1016/s0006-291x(02)02894-2. PMID 12504111.

Further reading

This article is issued from Wikipedia - version of the Wednesday, December 09, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.