INSM1

Insulinoma-associated 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LV2​, 3ZMS​
Identifiers
Symbols	INSM1 ; IA-1; IA1
External IDs	OMIM: 600010 MGI: 1859980 HomoloGene: 31080 GeneCards: INSM1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • core promoter binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription • sequence-specific DNA binding transcription factor activity • cyclin binding • chromatin DNA binding • histone deacetylase binding • metal ion binding Cellular component • nucleus • nucleoplasm • transcriptional repressor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • negative regulation of protein phosphorylation • type B pancreatic cell differentiation • pancreatic A cell differentiation • type B pancreatic cell development • noradrenergic neuron development • transcription, DNA-templated • cell cycle • negative regulation of cell proliferation • regulation of gene expression • positive regulation of cell migration • endocrine pancreas development • norepinephrine biosynthetic process • regulation of protein complex assembly • positive regulation of cell differentiation • transdifferentiation • adrenal chromaffin cell differentiation • sympathetic ganglion development • positive regulation of cell cycle arrest • positive regulation of neural precursor cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3642	53626
Ensembl	ENSG00000173404	ENSMUSG00000068154
UniProt	Q01101	Q63ZV0
RefSeq (mRNA)	NM_002196	NM_016889
RefSeq (protein)	NP_002187	NP_058585
Location (UCSC)	Chr 20: 20.37 – 20.37 Mb	Chr 2: 146.22 – 146.23 Mb
PubMed search

Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.^[1][2][3]

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.^[3]

Interactions

INSM1 has been shown to interact with SORBS1.^[4]

References

1. Lan MS, Li Q, Lu J, Modi WS, Notkins AL (Jun 1994). "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1". J Biol Chem 269 (19): 14170–4. PMID 8188699.
2. Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS (Jun 2006). "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases". Biochem J 397 (1): 169–77. doi:10.1042/BJ20051669. PMC 1479746. PMID 16569215.
3. "Entrez Gene: INSM1 insulinoma-associated 1".
4. Xie, Jingping; Cai Tao; Zhang Honglai; Lan Michael S; Notkins Abner Louis (Jul 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics (United States) 80 (1): 54–61. doi:10.1006/geno.2002.6800. ISSN 0888-7543. PMC 1237014. PMID 12079283.

Further reading

• Goto Y, De Silva MG, Toscani A, et al. (1992). "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs.". J. Biol. Chem. 267 (21): 15252–7. PMID 1634555.
• Li Q, Notkins AL, Lan MS (1997). "Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1.". Biochem. Biophys. Res. Commun. 236 (3): 776–81. doi:10.1006/bbrc.1997.7054. PMID 9245732.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Breslin MB, Zhu M, Notkins AL, Lan MS (2002). "Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence.". Nucleic Acids Res. 30 (4): 1038–45. doi:10.1093/nar/30.4.1038. PMC 100352. PMID 11842116.
• Zhu M, Breslin MB, Lan MS (2002). "Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells.". Pancreas 24 (2): 139–45. doi:10.1097/00006676-200203000-00004. PMID 11854618.
• Xie J, Cai T, Zhang H, et al. (2003). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.". Genomics 80 (1): 54–61. doi:10.1006/geno.2002.6800. PMC 1237014. PMID 12079283.
• Breslin MB, Zhu M, Lan MS (2003). "NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.". J. Biol. Chem. 278 (40): 38991–7. doi:10.1074/jbc.M306795200. PMC 1236987. PMID 12890672.
• Tao Zhang, Breslin MB, Lan MS (2009). "Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest.". J. Biol. Chem. 284 (9): 5574–81. doi:10.1074/jbc.M808843200. PMC 2645817. PMID 19124461.