IPO8

Importin 8
Identifiers
Symbols	IPO8 ; RANBP8
External IDs	OMIM: 605600 HomoloGene: 48430 GeneCards: IPO8 Gene
Gene ontology Molecular function • protein binding • Ran GTPase binding Cellular component • nucleoplasm • cytosol Biological process • intracellular protein transport • signal transduction • gene expression Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10526	320727
Ensembl	ENSG00000133704	ENSMUSG00000040029
UniProt	O15397	Q7TMY7
RefSeq (mRNA)	NM_001190995	NM_001081113
RefSeq (protein)	NP_001177924	NP_001074582
Location (UCSC)	Chr 12: 30.63 – 30.7 Mb	Chr 6: 148.77 – 148.83 Mb
PubMed search

Importin 8 is a protein that in humans is encoded by the IPO8 gene.^[1]

Function

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

References

1. "Entrez Gene: Importin 8".

Further reading

• Görlich, D.; Dabrowski, M.; Bischoff, F. R.; Kutay, U.; Bork, P.; Hartmann, E.; Prehn, S.; Izaurralde, E. (1997). "A novel class of RanGTP binding proteins". The Journal of Cell Biology 138 (1): 65–80. doi:10.1083/jcb.138.1.65. PMC 2139951. PMID 9214382.
• Nozawa, R. S.; Nagao, K.; Masuda, H. T.; Iwasaki, O.; Hirota, T.; Nozaki, N.; Kimura, H.; Obuse, C. (2010). "Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation". Nature Cell Biology 12 (7): 719–727. doi:10.1038/ncb2075. PMID 20562864.
• Lunetta, K. L.; d'Agostino Rb, R. B.; Karasik, D.; Benjamin, E. J.; Guo, C. Y.; Govindaraju, R.; Kiel, D. P.; Kelly-Hayes, M.; Massaro, J. M.; Pencina, M. J.; Seshadri, S.; Murabito, J. M. (2007). "Genetic correlates of longevity and selected age-related phenotypes: A genome-wide association study in the Framingham Study". BMC Medical Genetics 8: S13. doi:10.1186/1471-2350-8-S1-S13. PMC 1995604. PMID 17903295.
• Nguewa, P. A.; Agorreta, J.; Blanco, D.; Lozano, M.; Gomez-Roman, J.; Sanchez, B. A.; Valles, I. A.; Pajares, M. J.; Pio, R.; Rodriguez, M.; Montuenga, L. M.; Calvo, A. (2008). "Identification of Importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens". BMC Molecular Biology 9: 103. doi:10.1186/1471-2199-9-103. PMC 2612021. PMID 19014639.
• Dean, K. A.; Von Ahsen, O.; Görlich, D.; Fried, H. M. (2001). "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin". Journal of Cell Science 114 (Pt 19): 3479–3485. PMID 11682607.
• Weinmann, L.; Höck, J.; Ivacevic, T.; Ohrt, T.; Mütze, J. R.; Schwille, P.; Kremmer, E.; Benes, V.; Urlaub, H.; Meister, G. (2009). "Importin 8 is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs". Cell 136 (3): 496–507. doi:10.1016/j.cell.2008.12.023. PMID 19167051.
• Yao, X.; Chen, X.; Cottonham, C.; Xu, L. (2008). "Preferential Utilization of Imp7/8 in Nuclear Import of Smads". Journal of Biological Chemistry 283 (33): 22867–22874. doi:10.1074/jbc.M801320200. PMC 2504884. PMID 18519565.
• Zuo, S.; Xue, Y.; Tang, S.; Yao, J.; Du, R.; Yang, P.; Chen, X. (2010). "14-3-3 Epsilon Dynamically Interacts with Key Components of Mitogen-Activated Protein Kinase Signal Module for Selective Modulation of the TNF-α-Induced Time Course-Dependent NF-κB Activity". Journal of Proteome Research 9 (7): 3465–3478. doi:10.1021/pr9011377. PMID 20462248.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.