ISG20

Interferon stimulated exonuclease gene 20kDa
PDB rendering based on 1wlj.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1WLJ​
Identifiers
Symbols	ISG20 ; CD25; HEM45
External IDs	OMIM: 604533 MGI: 1928895 HomoloGene: 31081 GeneCards: ISG20 Gene
EC number	3.1.13.1
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • exonuclease activity • single-stranded DNA 3'-5' exodeoxyribonuclease activity • exoribonuclease II activity • U1 snRNA binding • U2 snRNA binding • U3 snoRNA binding • metal ion binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • Cajal body • PML body Biological process • DNA catabolic process, exonucleolytic • rRNA processing • RNA catabolic process • cell proliferation • response to virus • cytokine-mediated signaling pathway • negative regulation of viral genome replication • defense response to virus • type I interferon signaling pathway • RNA phosphodiester bond hydrolysis, exonucleolytic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3669	57444
Ensembl	ENSG00000172183	ENSMUSG00000039236
UniProt	Q96AZ6	Q9JL16
RefSeq (mRNA)	NM_001303233	NM_001113527
RefSeq (protein)	NP_001290162	NP_001106999
Location (UCSC)	Chr 15: 88.64 – 88.66 Mb	Chr 7: 78.91 – 78.92 Mb
PubMed search

Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene.^[1][2][3]

References

1. Gongora C, David G, Pintard L, Tissot C, Hua TD, Dejean A, Mechti N (Aug 1997). "Molecular cloning of a new interferon-induced PML nuclear body-associated protein". The Journal of Biological Chemistry 272 (31): 19457–63. doi:10.1074/jbc.272.31.19457. PMID 9235947.
2. Mattei MG, Tissot C, Gongora C, Mechti N (Jun 1998). "Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization". Cytogenetics and Cell Genetics 79 (3-4): 286–7. doi:10.1159/000134745. PMID 9605874.
3. "Entrez Gene: ISG20 interferon stimulated exonuclease gene 20kDa".

Further reading

• Pentecost BT (Jan 1998). "Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus". The Journal of Steroid Biochemistry and Molecular Biology 64 (1-2): 25–33. doi:10.1016/S0960-0760(97)00140-4. PMID 9569007.
• Nguyen LH, Espert L, Mechti N, Wilson DM (Jun 2001). "The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro". Biochemistry 40 (24): 7174–9. doi:10.1021/bi010141t. PMID 11401564.
• Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (Feb 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Espert L, Degols G, Gongora C, Blondel D, Williams BR, Silverman RH, Mechti N (May 2003). "ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses". The Journal of Biological Chemistry 278 (18): 16151–8. doi:10.1074/jbc.M209628200. PMID 12594219.
• Horio T, Murai M, Inoue T, Hamasaki T, Tanaka T, Ohgi T (Nov 2004). "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease". FEBS Letters 577 (1-2): 111–6. doi:10.1016/j.febslet.2004.09.074. PMID 15527770.