ITGB3BP

Integrin beta 3 binding protein (beta3-endonexin)
Identifiers
Symbols	ITGB3BP ; CENP-R; CENPR; HSU37139; NRIF3; TAP20
External IDs	OMIM: 605494 MGI: 1914983 HomoloGene: 8617 GeneCards: ITGB3BP Gene
Gene ontology Molecular function • signal transducer activity • protein binding • protein C-terminus binding Cellular component • condensed chromosome kinetochore • nucleus • nucleoplasm • cytoplasm • cytosol • membrane Biological process • mitotic cell cycle • nucleosome assembly • transcription, DNA-templated • regulation of transcription, DNA-templated • mitotic nuclear division • cell adhesion • signal transduction • small GTPase mediated signal transduction • CENP-A containing nucleosome assembly • positive regulation of apoptotic process • neurotrophin TRK receptor signaling pathway • cell division • apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23421	67733
Ensembl	ENSG00000142856	ENSMUSG00000028549
UniProt	Q13352	Q9CQ82
RefSeq (mRNA)	NM_001206739	NM_026348
RefSeq (protein)	NP_001193668	NP_080624
Location (UCSC)	Chr 1: 63.44 – 63.59 Mb	Chr 4: 99.77 – 99.93 Mb
PubMed search

Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.^[1][2][3]

Interactions

ITGB3BP has been shown to interact with:

• CD61,^[1][4]
• Cyclin A2,^[5]
• NFKB1,^[6]
• RXRA,^[2]
• RXRG,^[7] and
• THRA.^[2][7]

References

1. Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH (December 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J Cell Biol 131 (3): 807–16. doi:10.1083/jcb.131.3.807. PMC 2120613. PMID 7593198.
2. Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH (February 2000). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Mol Cell Biol 19 (10): 7191–202. PMC 84712. PMID 10490654.
3. "Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin)".
4. Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (January 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. 105 (1): 63–70. doi:10.1016/s0049-3848(01)00405-4. PMID 11864709.
5. Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (January 2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase". Biochem. Biophys. Res. Commun. 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. PMID 10673397.
6. Besta F, Massberg S, Brand K, Müller E, Page S, Grüner S, Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M (October 2002). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell. Sci. 115 (Pt 20): 3879–88. doi:10.1242/jcs.00081. PMID 12244126.
7. Li D, Wang F, Samuels HH (December 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274.

Further reading

• Kashiwagi H, Schwartz MA, Eigenthaler M, Davis KA, Ginsberg MH, Shattil SJ (1997). "Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail.". J. Cell Biol. 137 (6): 1433–43. doi:10.1083/jcb.137.6.1433. PMC 2132534. PMID 9182673.
• Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein.". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC 2169340. PMID 10579726.
• Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase.". Biochem. Biophys. Res. Commun. 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. PMID 10673397.
• Li D, Wang F, Samuels HH (2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation.". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274.
• Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (2002). "Novel alternatively spliced form of beta(3)-endonexin.". Thromb. Res. 105 (1): 63–70. doi:10.1016/S0049-3848(01)00405-4. PMID 11864709.
• Besta F, Massberg S, Brand K, Müller E, Page S, Grüner S, Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M (2003). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.". J. Cell. Sci. 115 (Pt 20): 3879–88. doi:10.1242/jcs.00081. PMID 12244126.
• Li D, Das S, Yamada T, Samuels HH (2004). "The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells.". Mol. Cell. Biol. 24 (9): 3838–48. doi:10.1128/MCB.24.9.3838-3848.2004. PMC 387764. PMID 15082778.
• Talukder AH, Gururaj A, Mishra SK, Vadlamudi RK, Kumar R (2004). "Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.". Mol. Cell. Biol. 24 (15): 6581–91. doi:10.1128/MCB.24.15.6581-6591.2004. PMC 444867. PMID 15254226.
• Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (2006). "The human CENP-A centromeric nucleosome-associated complex.". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.
• Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.". Nat. Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.