ITIH1

Inter-alpha-trypsin inhibitor heavy chain 1
Identifiers
Symbols	ITIH1 ; H1P; IATIH; IGHEP1; ITI-HC1; ITIH; SHAP
External IDs	OMIM: 147270 MGI: 96618 HomoloGene: 1667 GeneCards: ITIH1 Gene
Gene ontology Molecular function • serine-type endopeptidase inhibitor activity • calcium ion binding Cellular component • extracellular region • extracellular exosome • blood microparticle Biological process • negative regulation of endopeptidase activity • hyaluronan metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3697	16424
Ensembl	ENSG00000055957	ENSMUSG00000006529
UniProt	P19827	Q61702
RefSeq (mRNA)	NM_001166434	NM_001306078
RefSeq (protein)	NP_001159906	NP_001293007
Location (UCSC)	Chr 3: 52.78 – 52.79 Mb	Chr 14: 30.93 – 30.94 Mb
PubMed search

Inter-alpha-trypsin inhibitor heavy chain H1 is a protein that in humans is encoded by the ITIH1 gene.^[1][2][3]

See also

• Inter-alpha-trypsin inhibitor
• ITIH2
• ITIH3
• ITIH4

References

1. Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
2. Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603.
3. "Entrez Gene: ITIH1 inter-alpha (globulin) inhibitor H1".

Further reading

• Diarra-Mehrpour M, Bourguignon J, Bost F, et al. (1992). "Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1". Biochim. Biophys. Acta 1132 (1): 114–8. doi:10.1016/0167-4781(92)90065-8. PMID 1380832.
• Malki N, Balduyck M, Maes P, et al. (1992). "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A". Biol. Chem. Hoppe-Seyler 373 (10): 1009–18. doi:10.1515/bchm3.1992.373.2.1009. PMID 1384548.
• Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. doi:10.1073/pnas.84.23.8272. PMC 299524. PMID 2446322.
• Diarra-Mehrpour M, Bourguignon J, Sesboüé R, et al. (1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur. J. Biochem. 179 (1): 147–54. doi:10.1111/j.1432-1033.1989.tb14532.x. PMID 2465147.
• Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E (1989). "Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related". Eur. J. Biochem. 181 (3): 571–6. doi:10.1111/j.1432-1033.1989.tb14762.x. PMID 2471637.
• Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan". J. Biol. Chem. 264 (27): 15975–81. PMID 2476436.
• Schreitmüller T, Hochstrasser K, Reisinger PW, et al. (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler 368 (8): 963–70. doi:10.1515/bchm3.1987.368.2.963. PMID 3663330.
• Huang L, Yoneda M, Kimata K (1994). "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor". J. Biol. Chem. 268 (35): 26725–30. PMID 7504674.
• Bost F, Bourguignon J, Martin JP, et al. (1994). "Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene". Eur. J. Biochem. 218 (2): 283–91. doi:10.1111/j.1432-1033.1993.tb18376.x. PMID 7505744.
• Morelle W, Capon C, Balduyck M, et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". Eur. J. Biochem. 221 (2): 881–8. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643.
• Diarra-Mehrpour M, Bourguignon J, Sarafan N, et al. (1994). "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes". Biochim. Biophys. Acta 1219 (2): 551–4. doi:10.1016/0167-4781(94)90087-6. PMID 7522574.
• Ding M, Umetsu K, Yuasa I, et al. (1995). "Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism". Hum. Genet. 95 (4): 435–6. doi:10.1007/BF00208970. PMID 7535743.
• Zhao M, Yoneda M, Ohashi Y, et al. (1995). "Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan". J. Biol. Chem. 270 (44): 26657–63. doi:10.1074/jbc.270.44.26657. PMID 7592891.
• Bourguignon J, Diarra-Mehrpour M, Thiberville L, et al. (1993). "Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence". Eur. J. Biochem. 212 (3): 771–6. doi:10.1111/j.1432-1033.1993.tb17717.x. PMID 7681778.
• Olsen EH, Rahbek-Nielsen H, Thogersen IB, et al. (1998). "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2". Biochemistry 37 (1): 408–16. doi:10.1021/bi971137d. PMID 9425062.
• Flahaut C, Capon C, Balduyck M, et al. (1998). "Glycosylation pattern of human inter-alpha-inhibitor heavy chains". Biochem. J. 333 ( Pt 3) (Pt 3): 749–56. PMC 1219641. PMID 9677337.
• Flahaut C, Mizon C, Aumercier-Maes P, et al. (1998). "Disulphide bonds assignment in the inter-alpha-inhibitor heavy chains--structural and functional implications". Eur. J. Biochem. 255 (1): 107–15. doi:10.1046/j.1432-1327.1998.2550107.x. PMID 9692908.
• Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. doi:10.1074/jbc.273.41.26809. PMID 9756925.