ITPKB

Inositol-trisphosphate 3-kinase B
PDB rendering based on 2aqx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2aqx​
Identifiers
Symbols	ITPKB ; IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37
External IDs	OMIM: 147522 MGI: 109235 HomoloGene: 1672 ChEMBL: 5165 GeneCards: ITPKB Gene
EC number	2.7.1.127
Gene ontology Molecular function • protein binding • calmodulin binding • ATP binding • inositol-1,4,5-trisphosphate 3-kinase activity Cellular component • cytosol Biological process • MAPK cascade • signal transduction • cell surface receptor signaling pathway • inositol phosphate metabolic process • small molecule metabolic process • positive thymic T cell selection • positive regulation of Ras protein signal transduction • positive regulation of alpha-beta T cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3707	320404
Ensembl	ENSG00000143772	ENSMUSG00000038855
UniProt	P27987	B2RXC2
RefSeq (mRNA)	NM_002221	NM_001081175
RefSeq (protein)	NP_002212	NP_001074644
Location (UCSC)	Chr 1: 226.63 – 226.74 Mb	Chr 1: 180.33 – 180.42 Mb
PubMed search

Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene.^[1][2]

Function

The protein encoded by this gene regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.^[3] Itpkb regulates immune cell function and is required for T and B cell development.^[4]

References

1. Takazawa K, Perret J, Dumont JE, Erneux C (Oct 1991). "Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme". Biochem J 278 (3): 883–6. PMC 1151429. PMID 1654894.
2. Erneux C, Roeckel N, Takazawa K, Mailleux P, Vassart G, Mattei MG (Dec 1992). "Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization". Genomics 14 (2): 546–7. doi:10.1016/S0888-7543(05)80265-4. PMID 1330886.
3. "Entrez Gene: ITPKB inositol 1,4,5-trisphosphate 3-kinase B".
4. Sauer K, Cooke MP (April 2010). "Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate". Nat. Rev. Immunol. 10 (4): 257–71. doi:10.1038/nri2745. PMC 2922113. PMID 20336153.

Further reading

• Szlufcik K, Missiaen L, Parys JB, et al. (2006). "Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences.". Biol. Cell 98 (1): 1–14. doi:10.1042/BC20050031. PMID 16354157.