IVNS1ABP

Influenza virus NS1A binding protein
Identifiers
Symbols	IVNS1ABP ; FLARA3; HSPC068; KLHL39; ND1; NS-1; NS1-BP; NS1BP
External IDs	OMIM: 609209 MGI: 2152389 HomoloGene: 31384 GeneCards: IVNS1ABP Gene
Gene ontology Molecular function • receptor activity • protein binding Cellular component • nucleoplasm • transcription factor complex • spliceosomal complex • cytoplasm • actin cytoskeleton Biological process • transcription from RNA polymerase III promoter • RNA splicing • response to virus • viral process • negative regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10625	117198
Ensembl	ENSG00000116679	ENSMUSG00000023150
UniProt	Q9Y6Y0	Q920Q8
RefSeq (mRNA)	NM_006469	NM_001039511
RefSeq (protein)	NP_006460	NP_001034600
Location (UCSC)	Chr 1: 185.3 – 185.32 Mb	Chr 1: 151.34 – 151.36 Mb
PubMed search

Influenza virus NS1A-binding protein is a protein that in humans is encoded by the IVNS1ABP gene.^[1][2][3]

In melanocytic cells IVNS1ABP gene expression may be regulated by MITF.^[4]

References

1. Wolff T, O'Neill RE, Palese P (Sep 1998). "NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells". J Virol 72 (9): 7170–80. PMC 109939. PMID 9696811.
2. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
3. "Entrez Gene: IVNS1ABP influenza virus NS1A binding protein".
4. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

• Perconti G, Ferro A, Amato F, et al. (2008). "The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.". Biochim. Biophys. Acta 1773 (12): 1774–85. doi:10.1016/j.bbamcr.2007.09.002. PMID 17996313.
• Dunham EE, Stevens EA, Glover E, Bradfield CA (2006). "The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein.". Mol. Pharmacol. 70 (1): 8–15. doi:10.1124/mol.106.024380. PMID 16582008.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Harris CE, Boden RA, Astell CR (1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice.". J. Virol. 73 (1): 72–80. PMC 103810. PMID 9847309.