IZUMO1
| Izumo sperm-egg fusion 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | IZUMO1 ; IZUMO | ||||||||||||
| External IDs | OMIM: 609278 HomoloGene: 77701 GeneCards: IZUMO1 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 284359 | 73456 | |||||||||||
| Ensembl | ENSG00000182264 | ENSMUSG00000064158 | |||||||||||
| UniProt | Q8IYV9 | Q9D9J7 | |||||||||||
| RefSeq (mRNA) | NM_182575 | NM_001018013 | |||||||||||
| RefSeq (protein) | NP_872381 | NP_001018013 | |||||||||||
| Location (UCSC) |
Chr 19: 48.74 – 48.75 Mb |
Chr 7: 45.62 – 45.63 Mb | |||||||||||
| PubMed search | |||||||||||||
Izumo sperm-egg fusion 1 is a protein that in humans is encoded by the IZUMO1 gene.[1]
Function
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion.[2]
References
- ↑ "Entrez Gene: Izumo sperm-egg fusion 1".
- ↑ Inoue N, Ikawa M, Isotani A, Okabe M (2005). "The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs". Nature 434 (7030): 234–8. doi:10.1038/nature03362. PMID 15759005.
Further reading
- Chu AY, Workalemahu T, Paynter NP, Rose LM, Giulianini F, Tanaka T, Ngwa JS, Qi Q, Curhan GC, Rimm EB, Hunter DJ, Pasquale LR, Ridker PM, Hu FB, Chasman DI, Qi L (2013). "Novel locus including FGF21 is associated with dietary macronutrient intake". Human Molecular Genetics 22 (9): 1895–902. doi:10.1093/hmg/ddt032. PMC 3612009. PMID 23372041.
- Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (2006). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Hum. Mol. Genet. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID 17047026.
- Granados-Gonzalez V, Aknin-Seifer I, Touraine RL, Chouteau J, Wolf JP, Levy R (2008). "Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure". Fertil. Steril. 90 (4): 1246–8. doi:10.1016/j.fertnstert.2007.09.008. PMID 18082733.
- Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P (2009). "Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm". Mol. Reprod. Dev. 76 (12): 1188–99. doi:10.1002/mrd.21092. PMC 3779078. PMID 19658160.
- Grayson P, Civetta A (2012). "Positive Selection and the Evolution of izumo Genes in Mammals". Int J Evol Biol 2012: 958164. doi:10.1155/2012/958164. PMC 3432370. PMID 22957301.
- Inoue N, Ikawa M, Okabe M (2008). "Putative sperm fusion protein IZUMO and the role of N-glycosylation". Biochem. Biophys. Res. Commun. 377 (3): 910–4. doi:10.1016/j.bbrc.2008.10.073. PMID 18952059.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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