FCN3

Ficolin (collagen/fibrinogen domain containing) 3
PDB rendering based on 2j5z.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1LA5​, 2J5Z​, 2J60​, 2J64​
Identifiers
Symbols	FCN3 ; FCNH; HAKA1
External IDs	OMIM: 604973 HomoloGene: 130523 GeneCards: FCN3 Gene
Gene ontology Molecular function • antigen binding • protein binding • carbohydrate binding • carbohydrate derivative binding Cellular component • extracellular region • collagen trimer • blood microparticle Biological process • complement activation, lectin pathway • complement activation • recognition of apoptotic cell • innate immune response • negative regulation of viral entry into host cell • defense response to virus • negative regulation of RNA biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8547	n/a
Ensembl	ENSG00000142748	n/a
UniProt	O75636	n/a
RefSeq (mRNA)	NM_003665	n/a
RefSeq (protein)	NP_003656	n/a
Location (UCSC)	Chr 1: 27.37 – 27.37 Mb	n/a
PubMed search		n/a

Ficolin-3 is a protein that in humans is encoded by the FCN3 gene. Ficolin-3 was initially identified as H-ficolin, in which H is after the Hakata antigen that was previously found as an autoantigen in patients who lived in the city of Hakata. ^[1][2][3]

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.^[3]

References

1. Sugimoto R, Yae Y, Akaiwa M, Kitajima S, Shibata Y, Sato H, Hirata J, Okochi K, Izuhara K, Hamasaki N (Sep 1998). "Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family". J Biol Chem 273 (33): 20721–7. doi:10.1074/jbc.273.33.20721. PMID 9694814.
2. Akaiwa M, Yae Y, Sugimoto R, Suzuki SO, Iwaki T, Izuhara K, Hamasaki N (Jun 1999). "Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile". J Histochem Cytochem 47 (6): 777–86. doi:10.1177/002215549904700607. PMID 10330454.
3. "Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)".

Further reading

• Yae Y, Inaba S, Sato H, (1991). "Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus". Biochim. Biophys. Acta 1078 (3): 369–76. doi:10.1016/0167-4838(91)90158-v. PMID 1859827.
• Inaba S, Okochi K, Yae Y, (1991). "Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system". Fukuoka Igaku Zasshi 81 (9): 284–91. PMID 2276712.
• Matsushita M, Kuraya M, Hamasaki N, (2002). "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)". J. Immunol. 168 (7): 3502–6. doi:10.4049/jimmunol.168.7.3502. PMID 11907111.
• Tsujimura M, Miyazaki T, Kojima E, (2003). "Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth". Clin. Chim. Acta 325 (1–2): 139–46. doi:10.1016/S0009-8981(02)00274-7. PMID 12367778.
• Strausberg RL, Feingold EA, Grouse LH, (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zeng L, Dai J, Ying K, (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
• Clark HF, Gurney AL, Abaya E, (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Anderson NL, Polanski M, Pieper R, (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Liu T, Qian WJ, Gritsenko MA, (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Muzny DM, Scherer SE, Kaul R, (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.
• Garlatti V, Belloy N, Martin L, (2007). "Structural insights into the innate immune recognition specificities of L- and H-ficolins". EMBO J. 26 (2): 623–33. doi:10.1038/sj.emboj.7601500. PMC 1783469. PMID 17215869.
• Honoré C, Hummelshoj T, Hansen BE, (2007). "The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells". Arthritis Rheum. 56 (5): 1598–607. doi:10.1002/art.22564. PMID 17469142.