Immunoglobulin heavy constant alpha 1

Immunoglobulin heavy constant alpha 1
Available structures PDB Human UniProt search: PDBe, RCSB List of PDB id codes 1IGA​, 1OW0​, 2QEJ​, 2QTJ​
Identifiers
Symbols	IGHA1 ; IgA1
External IDs	OMIM: 146900 GeneCards: IGHA1 Gene
Gene ontology Molecular function • antigen binding • immunoglobulin receptor binding Cellular component • extracellular region • extracellular space • extracellular exosome • monomeric IgA immunoglobulin complex • secretory IgA immunoglobulin complex • secretory dimeric IgA immunoglobulin complex • blood microparticle Biological process • retina homeostasis • glomerular filtration • receptor-mediated endocytosis • immune response • protein-chromophore linkage • antibacterial humoral response • positive regulation of respiratory burst Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3493	n/a
Ensembl	n/a	n/a
UniProt	P01876	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search		n/a

Ig alpha-1 chain C region is a protein that in humans is encoded by the IGHA1 gene.^[1]

References

1. "Entrez Gene: IGHA1 immunoglobulin heavy constant alpha 1".

Further reading

• Kerr MA (1990). "The structure and function of human IgA.". Biochem. J. 271 (2): 285–96. PMC 1149552. PMID 2241915.
• Putnam FW, Liu YS, Low TL (1979). "Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain.". J. Biol. Chem. 254 (8): 2865–74. PMID 107164.
• Yang C, Kratzin H, Götz H, Hilschmann N (1980). "[Rule of antibody structure. Primary structure of a human monoclonal IgA-immunoglobulin (myeloma protein Tro). VII. Purification and characterization of the disulfide bridges]". Hoppe-Seyler's Z. Physiol. Chem. 360 (12): 1919–40. PMID 393607.
• Kratzin H, Altevogt P, Ruban E, et al. (1975). "[The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 356 (8): 1337–42. PMID 809331.
• Flanagan JG, Lefranc MP, Rabbitts TH (1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences.". Cell 36 (3): 681–8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489.
• Takahashi N, Ueda S, Obata M, et al. (1982). "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family.". Cell 29 (2): 671–9. doi:10.1016/0092-8674(82)90183-0. PMID 6811139.
• Calero M, Escribano J, Grubb A, Méndez E (1994). "Location of a novel type of interpolypeptide chain linkage in the human protein HC-IgA complex (HC-IgA) and identification of a heterogeneous chromophore associated with the complex.". J. Biol. Chem. 269 (1): 384–9. PMID 7506257.
• Pleass RJ, Dunlop JI, Anderson CM, Woof JM (1999). "Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89.". J. Biol. Chem. 274 (33): 23508–14. doi:10.1074/jbc.274.33.23508. PMID 10438530.
• McLean GR, Nakouzi A, Casadevall A, Green NS (2001). "Human and murine immunoglobulin expression vector cassettes.". Mol. Immunol. 37 (14): 837–45. doi:10.1016/S0161-5890(00)00101-2. PMID 11257305.
• Gala FA, Morrison SL (2002). "The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1.". J. Biol. Chem. 277 (32): 29005–11. doi:10.1074/jbc.M203258200. PMID 12023968.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kristiansen TZ, Bunkenborg J, Gronborg M, et al. (2005). "A proteomic analysis of human bile.". Mol. Cell Proteomics 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671.
• Senior BW, Woof JM (2005). "Effect of mutations in the human immunoglobulin A1 (IgA1) hinge on its susceptibility to cleavage by diverse bacterial IgA1 proteases.". Infect. Immun. 73 (3): 1515–22. doi:10.1128/IAI.73.3.1515-1522.2005. PMC 1064975. PMID 15731049.
• Wines BD, Willoughby N, Fraser JD, Hogarth PM (2006). "A competitive mechanism for staphylococcal toxin SSL7 inhibiting the leukocyte IgA receptor, Fc alphaRI, is revealed by SSL7 binding at the C alpha2/C alpha3 interface of IgA.". J. Biol. Chem. 281 (3): 1389–93. doi:10.1074/jbc.M509334200. PMID 16293625.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Almogren A, Furtado PB, Sun Z, et al. (2006). "Purification, properties and extended solution structure of the complex formed between human immunoglobulin A1 and human serum albumin by scattering and ultracentrifugation.". J. Mol. Biol. 356 (2): 413–31. doi:10.1016/j.jmb.2005.11.060. PMID 16376934.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Geng LY, Shi ZZ, Dong Q, et al. (2007). "Expression of SNC73, a transcript of the immunoglobulin alpha-1 gene, in human epithelial carcinomas.". World J. Gastroenterol. 13 (16): 2305–11. doi:10.3748/wjg.v13.i16.2305. PMID 17511028.