Indacrinone

Indacrinone
Systematic (IUPAC) name

[(6,7-Dichloro-2-methyl-1-oxo-2-phenyl-2,3-dihydro-1H-inden-5-yl)oxy]acetic acid
Identifiers
CAS Number	56049-88-8
PubChem	CID 42266
ChemSpider	38545
Chemical data
Formula	C₁₈H₁₄Cl₂O₄
Molar mass	365.21 g/mol
SMILES CC1(Cc2cc(c(c(c2C1=O)Cl)Cl)OCC(=O)O)c3ccccc3
InChI InChI=1S/C18H14Cl2O4/c1-18(11-5-3-2-4-6-11)8-10-7-12(24-9-13(21)22)15(19)16(20)14(10)17(18)23/h2-7H,8-9H2,1H3,(H,21,22) Key:PRKWVSHZYDOZLP-UHFFFAOYSA-N

Indacrinone is a loop diuretic. It can be used in patients of gout with hypertension as an antihypertensive because it decreases reabsorption of uric acid,^[1] while other diuretics increase it.

References

↑ Vlasses, P. H.; Rotmensch, H. H.; Swanson, B. N.; Irvin, J. D.; Johnson, C. L.; Ferguson, R. K. (1984). "Indacrinone: Natriuretic and uricosuric effects of various ratios of its enantiomers in healthy men". Pharmacotherapy 4 (5): 272–7. doi:10.1002/j.1875-9114.1984.tb03374.x. PMID 6504708.

This article is issued from Wikipedia - version of the Saturday, April 02, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.