Indazole
 | |||
| |||
| Names | |||
|---|---|---|---|
| IUPAC name
1H-indazole | |||
| Identifiers | |||
271-44-3  | |||
| ChEBI | CHEBI:36670 | ||
| ChEMBL | ChEMBL86795 | ||
| ChemSpider | 8866 | ||
| Jmol interactive 3D | Image | ||
| PubChem | 9221 | ||
| |||
| |||
| Properties | |||
| C7H6N2 | |||
| Molar mass | 118.14 g/mol | ||
| Melting point | 147 to 149 °C (297 to 300 °F; 420 to 422 K) | ||
| Boiling point | 270 °C (518 °F; 543 K) | ||
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |||
verify (what is  ?) | |||
| Infobox references | |||
Indazole, also called isoindazole, is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and pyrazole.
Indazole derivatives display a broad variety of biological activities.
Indazoles are rare in nature. The alkaloids nigellicine, nigeglanine, and nigellidine are indazoles. Nigellicine was isolated from the widely distributed plant Nigella sativa L. (black cumin). Nigeglanine was isolated from extracts of Nigella glandulifera.
The Davis–Beirut reaction can generate 2H-indazoles.
Some derivatives
- indazole-3-carboxylic acid
- Having a carboxylic acid group on carbon 3. Can be further modified to lonidamine.
See also
- Indole, an analog with only one nitrogen atom in position 1.
- Benzimidazole, an analog with the nitrogen atoms in positions 1 and 3.
- Simple aromatic rings
- 7-Nitroindazole, an indazole-based nitric oxide synthase inhibitor
References
- Synthesis: W. Stadlbauer, in Science of Synthesis 2002, 12, 227, and W. Stadlbauer, in Houben-Weyl, 1994, E8b, 764.
- Review: A. Schmidt, A. Beutler, B. Snovydovych, Recent Advances in the Chemistry of Indazoles, Eur. J. Org. Chem. 2008, 4073 – 4095.
This article is issued from Wikipedia - version of the Sunday, April 03, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.