Indium (111In) biciromab

Indium (111In) biciromab
Monoclonal antibody
Type Fab' fragment
Source Mouse
Target Fibrin II, beta chain
Clinical data
Trade names FibriScint
Pregnancy
category
  • N/A
Legal status
  • Withdrawn
Identifiers
CAS Number 138783-13-8 N
ATC code None
ChemSpider none
KEGG D03111 YesY
 NYesY (what is this?)  (verify)

Indium (111In) biciromab (INN, trade name FibriScint, developed by Centocor) was a drug targeting fibrin, a protein involved in the clotting of blood.[1] It was the Fab' fragment of a mouse monoclonal antibody labelled with the radioisotope indium-111 for the diagnosis of thromboembolism,[2] but was withdrawn during clinical trials.[3]

References

  1. King, David J.; John R. Adair (1999). "Recombinant antibodies for the diagnosis and therapy of human disease". Current Opinion in Drug Discovery & Development 2 (2): 112. ISSN 1367-6733.
  2. Answers.com: Centocor Ortho Biotech Products, L.P.
  3. DiagnosticImaging.com: Centocor withdraws imaging agent applications


This article is issued from Wikipedia - version of the Thursday, November 19, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.