Indole-3-glycerol-phosphate lyase

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming). Other names in common use include tryptophan synthase alpha, TSA, indoleglycerolphosphate aldolase, indole glycerol phosphate hydrolase, indole synthase, indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase, indole-3-glycerol phosphate lyase, IGL, BX1, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate, and D-glyceraldehyde-3-phosphate-lyase. This enzyme participates in benzoxazinone biosynthesis.

References

YANOFSKY C (1956). "The enzymatic conversion of anthranilic acid to indole". J. Biol. Chem. 223 (1): 171–84. PMID 13376586.
SP, Simcox K and Gierl A (1997). "Analysis of a chemical plant defense mechanism in grasses". Science 277 (5326): 696–699. doi:10.1126/science.277.5326.696. PMID 9235894.
Frey M, Stettner C, Pare PW, Schmelz EA, Tumlinson JH, Gierl A (2000). "An herbivore elicitor activates the gene for indole emission in maize". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14801–6. doi:10.1073/pnas.260499897. PMC 18999. PMID 11106389.
Melanson D, Chilton MD, Masters-Moore D, Chilton WS (1997). "A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 13345–50. doi:10.1073/pnas.94.24.13345. PMC 24311. PMID 9371848.

Carbon-carbon lyases (EC 4.1)

4.1.1: Carboxy-lyases	Acetoacetate decarboxylase Adenosylmethionine decarboxylase Aromatic L-amino acid decarboxylase Glutamate decarboxylase Histidine decarboxylase Lysine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Oxaloacetate decarboxylase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase Phosphoribosylaminoimidazole carboxylase Pyrophosphomevalonate decarboxylase Pyruvate decarboxylase RuBisCO Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase Uroporphyrinogen III decarboxylase

4.1.2: Aldehyde-lyases	Fructose-bisphosphate aldolase Aldolase A Aldolase B Aldolase C 2-hydroxyphytanoyl-CoA lyase Threonine aldolase

4.1.3: Oxo-acid-lyases	Isocitrate lyase 3-hydroxy-3-methylglutaryl-CoA lyase

4.1.99: Other	Tryptophanase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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