Inflammatory myofibroblastic tumour

Inflammatory myofibroblastic tumour

Micrograph of an inflammatory myofibroblastic tumour of the kidney. Kidney biopsy. H&E stain.
Classification and external resources
ICD-O M8825/1

Inflammatory myofibroblastic tumour is a lesional pattern of inflammatory pseudotumour, as plasma cell granuloma.[1] It is abbreviated IMT.

Symptoms

The symptoms depend on the specific location of the tumour, which can be anywhere in the body.[2]

Diagnosis

Inflammatory myofibroblastic tumours are diagnosed based on their appearance under the microscope, by pathologists.[3] Medical imaging findings are non-specific.

Pathology

Inflammatory myofibroblastic tumours are characterized by a mix of inflammatory cells, e.g. plasma cells, lymphocytes and eosinophils, and bland spindle cells without nuclear atypia. These tumours may have necrosis, hemorrhage, focal calcification and mitotic activity.

The histologic differential diagnosis includes:

Approximately half of IMTs have a rearrangement of the ALK gene.[4]

Localization

See also

References

  1. ↑ Manohar, B.; Bhuvaneshwari, S. (Jan 2011). "Plasma cell granuloma of gingiva.". J Indian Soc Periodontol 15 (1): 64–6. doi:10.4103/0972-124X.82275. PMC 3134051. PMID 21772725.
  2. ↑ Singhal, M.; Ramanathan, S.; Das, A.; Singh, G.; Bagga, R.; Khandelwal, N. (2011). "Omental inflammatory myofibroblastic tumour mimicking peritoneal carcinomatosis.". Cancer Imaging 11: 19–22. doi:10.1102/1470-7330.2011.0005. PMC 3080123. PMID 21435987.
  3. ↑ Soga, H.; Yao, A.; Matsushita, K.; Shimogaki, H.; Kawabata, G. (2011). "Inflammatory pseudotumor of the retroperitoneum removed via a retroperitoneoscopic approach.". JSLS 15 (2): 272–4. doi:10.4293/108680811X13071180406871. PMC 3148889. PMID 21902993.
  4. ↑ Gleason, BC.; Hornick, JL. (Apr 2008). "Inflammatory myofibroblastic tumours: where are we now?". J Clin Pathol 61 (4): 428–37. doi:10.1136/jcp.2007.049387. PMID 17938159.
  5. ↑ Kaitoukov, Y; Rakovich, G; Trahan, S; Grégoire, J (2011). "Inflammatory pseudotumour of the lung". Canadian respiratory journal : journal of the Canadian Thoracic Society 18 (6): 315–7. PMC 3267618. PMID 22187684.
  6. ↑ Sanchez, P. G.; Madke, G. R.; Pilla, E. S.; Foergnes, R; Felicetti, J. C.; Valle, Ed; Geyer, G (2007). "Endobronchial inflammatory pseudotumor: A case report". Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 33 (4): 484–6. PMID 17982543.
  7. ↑ Sari, A; Tunakan, M; Ünsal, B; Ekıncı, N; Rezanko, T; Elçın, F; Aydoğdu, Z (2010). "Inflammatory pseudotumor of the liver diagnosed by needle biopsy: Report of three cases (one with neuroendocrine tumor of the rectum and lung)". The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 21 (3): 308–12. PMID 20931439.
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