Insect pheromone-binding protein

Insect pheromone-binding family, A10/OS-D
antennal chemosensory protein a6 from the moth mamestra brassicae
Identifiers
Symbol	OS-D
Pfam	PF03392
InterPro	IPR005055
SCOP	1n8v
SUPERFAMILY	1n8v
OPM superfamily	377
OPM protein	1ow4
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the insect pheromone-binding family A10/OS-D is a family of proteins found in insects.

A class of small (14-20 Kd) water-soluble proteins, called odorant binding proteins (OBPs), first discovered in the insect sensillar lymph but also found in the mucus of vertebrates, is postulated to mediate the solubilisation of hydrophobic odorant molecules, and thereby to facilitate their transport to the receptor neurons. The product of a gene expressed in the olfactory system of Drosophila melanogaster (Fruit fly), OS-D, shares features common to vertebrate odorant-binding proteins, but has a primary structure unlike odorant-binding proteins.^[1] OS-D derivatives have subsequently been found in chemosensory organs of phylogenetically distinct insects, including cockroaches, phasmids and moths, suggesting that OS-D-like proteins seem to be conserved in the insect phylum. OS-D and related proteins are members of the insect pheromone-binding family A10/OS-D.

References

1. McKenna MP, Hekmat-Scafe DS, Gaines P, Carlson JR (June 1994). "Putative Drosophila pheromone-binding proteins expressed in a subregion of the olfactory system". J. Biol. Chem. 269 (23): 16340–7. PMID 8206941.

Further reading

• Angeli S, Ceron F, Scaloni A, Monti M, Monteforti G, Minnocci A, et al. (1999). "Purification, structural characterization, cloning and immunocytochemical localization of chemoreception proteins from Schistocerca gregaria.". Eur J Biochem 262 (3): 745–54. doi:10.1046/j.1432-1327.1999.00438.x. PMID 10411636.

This article incorporates text from the public domain Pfam and InterPro IPR005055