Insect repellent

A mosquito coil

An insect repellent (also commonly called "bug spray") is a substance applied to skin, clothing, or other surfaces which discourages insects (and arthropods in general) from landing or climbing on that surface. Insect repellents help prevent and control the outbreak of insect-borne (and other arthropod-bourne) diseases such as malaria, Lyme disease, dengue fever, bubonic plague, and West Nile fever. Pest animals commonly serving as vectors for disease include insects such as flea, fly, and mosquito; and the arachnid tick.

Common insect repellents

Oil Jar in cow horn for mosquito-repelling pitch oil, a by-product of the distillation of wood tar. Carried in a leather strap on a belt. Råneå, Norrbotten, since 1921 in Nordiska museet, Stockholm.[1]

Repellent effectiveness

A popular post-WWII Australian brand of insect repellent.

Synthetic repellents tend to be more effective and/or longer lasting than "natural" repellents.[9][10] In comparative studies, IR3535 was as effective or better than DEET in protection against mosquitoes.[11] Other sources (official publications of the associations of German physicians[12] as well as of German druggists[13] suggest the contrary and state DEET is still the most efficient substance available and the substance of choice for stays in malaria regions, while IR3535 has little effect. However, some plant-based repellents may provide effective relief as well.[9][10][14] Essential oil repellents can be short-lived in their effectiveness, since essential oils can evaporate completely.

A test of various insect repellents by an independent consumer organization found that repellents containing DEET or picaridin are more effective than repellents with "natural" active ingredients. All the synthetics gave almost 100% repellency for the first 2 hours, where the natural repellent products were most effective for the first 30 to 60 minutes, and required reapplication to be effective over several hours.[15]

For protection against mosquitos, the U.S. Centers for Disease Control (CDC) issued a statement in May 2008 recommending equally DEET, picaridin, oil of lemon eucalyptus and IR3535 for skin.[16] Permethrin is recommended for clothing, gear, or bed nets.[9] In an earlier report, the CDC found oil of lemon eucalyptus to be more effective than other plant-based treatments, with a similar effectiveness to low concentrations of DEET.[17] However, a 2006 published study found in both cage and field studies that a product containing 40% oil of lemon eucalyptus was just as effective as products containing high concentrations of DEET.[18] Research has also found that neem oil is mosquito repellent for up to 12 hours.[14] Citronella oil's mosquito repellency has also been verified by research,[19] including effectiveness in repelling Aedes aegypti,[20][21] but requires reapplication after 30 to 60 minutes.

More recently, in 2015, Researchers at New Mexico State University tested 10 commercially available products for their effectiveness at repelling mosquitoes.[22] On the mosquito Aedes aegypti, the vector of Zika virus, only one repellent that did not contain DEET had a strong effect for the duration of the 240 minutes test: a lemon eucalyptus oil repellent. All DEET-containing mosquito repellents were active.

There are also products available based on sound production, particularly ultrasound (inaudibly high frequency sounds) which purport to be insect repellents. However, these electronic devices have been shown to be ineffective based on studies done by the EPA and many universities.[23]

Repellent safety

DEET
Icaridin
p-Menthane-3,8-diol (PMD)

Regarding safety with insect repellent use on children and pregnant women:

Regardless of which repellent product used, it is recommended to read the label before use and carefully follow directions.[24] Usage instructions for repellents vary from country to country. Some insect repellents are not recommended for use on younger children.[16]

In the DEET Reregistration Eligibility Decision (RED) the United States Environmental Protection Agency (EPA) reported 14 to 46 cases of potential DEET associated seizures, including 4 deaths. The EPA states: "... it does appear that some cases are likely related to DEET toxicity," but observed that with 30% of the US population using DEET, the likely seizure rate is only about one per 100 million users.[25]

The Pesticide Information Project of Cooperative Extension Offices of Cornell University states that, "Everglades National Park employees having extensive DEET exposure were more likely to have insomnia, mood disturbances and impaired cognitive function than were lesser exposed co-workers".[26]

The EPA states that citronella oil shows little or no toxicity and has been used as a topical insect repellent for 60 years. However, the EPA also states that citronella may irritate skin and cause dermatitis in certain individuals.[5] Canadian regulatory authorities concern with citronella based repellents is primarily based on data-gaps in toxicology, not on incidents.[27][28]

Within countries of the European Union, implementation of Regulation 98/8/EC,[29] commonly referred to as the Biocidal Products Directive, has severely limited the number and type of insect repellents available to European consumers. Only a small number of active ingredients have been supported by manufacturers in submitting dossiers to the EU Authorities.

In general, only formulations containing DEET, icaridin (sold under the trade name Saltidin and formerly known as Bayrepel or KBR3023), IR3535 (3-[N-Butyl-N-acetyl]-aminopropionic acid, ethyl ester) and Citriodiol (p-menthane-3,8-diol) are available. Most "natural" insect repellents such as citronella, neem oil, and herbal extracts are no longer permitted for sale as insect repellents in the EU; this does not preclude them from being sold for other purposes, as long as the label does not indicate they are a biocide (insect repellent).

Insect repellents from natural sources

There are many preparations from naturally occurring sources that have been used as a repellent to certain insects. Some of these act as insecticides while others are only repellent.

Inactive substances – carriers

In 2002, the New England Journal of Medicine[53] published an article that found products containing essential oils such as catnip[54] or geranium oil, when combined with a suitable carrier oil such as soybean, have been found to be effective as natural repellents. This was based on testing done by Johns Hopkins[55] and Cornell Universities.[56] Other commercial products offered for household mosquito "control" include small electrical mats, mosquito repellent vapor, DEET-impregnated wrist bands, mosquito fogging, and mosquito coils containing a form of the chemical allethrin. Mosquito-repellent candles containing citronella oil are sold widely in the U.S. These have been used with mixed reports of success and failure.[57]

Less effective methods

Some old studies suggested that the ingestion of large doses of thiamine could be effective as an oral insect repellent against mosquito bites. However, there is now conclusive evidence that thiamin has no efficacy against mosquito bites.[58][59][60][61] Some claim that plants like wormwood or sagewort, lemon balm, lemon grass, lemon thyme and the mosquito plant (Pelargonium) will act against mosquitoes. However, scientists have determined that these plants are “effective” for a limited time only when the leaves are crushed and applied directly to the skin.[62]

There are several, widespread, unproven theories about mosquito control, such as the assertion that vitamin B, in particular B1 (thiamine), garlic, ultrasonic devices or incense can be used to repel or control mosquitoes.[59][63] Moreover, manufacturers of "mosquito repelling" ultrasonic devices have been found to be fraudulent,[64] and their devices were deemed "useless" in tests by the UK Consumer magazine Which?,[65] and according to a review of scientific studies.[66]

See also

References

  1. ↑ Comparisons explanatory text in the display: https://commons.wikimedia.org/wiki/File:Oil_Jar_in_cow_horn_for_mosquito-repelling_pitch_oil.JPG
  2. ↑ Happy people: A year in the Taiga
  3. ↑ Making birch bark tar
  4. ↑ Birch bark used as mosquito repellent
  5. 1 2 "Citronella (Oil of Citronella) (021901) Fact Sheet". United States Environmental Protection Agency. 16 February 2011. Retrieved 1 July 2011.
  6. ↑ Insect Repellents - Patent 6660288
  7. ↑ Detailed patent information
  8. ↑ Brown, Maryland Extension Service leaflet 10
  9. 1 2 3 M. S. Fradin and J. F. Day (2002). "Comparative Efficacy of Insect Repellents against Mosquito Bites". N Engl J Med 347 (1): 13–18. doi:10.1056/NEJMoa011699. PMID 12097535.
  10. 1 2 Collins, D.A.; Brady, J.N.; Curtis, C.F. (1993). "Assessment of the efficacy of Quwenling as a Mosquito repellent". Phytotherapy Research 7 (1): 17–20. doi:10.1002/ptr.2650070106.
  11. ↑ Cilek JE, Petersen JL, Hallmon CE. (2004). "Comparative efficacy of IR3535 and deet as repellents against adult Aedes aegypti and Culex quinquefasciatus.". J Am Mosq Control Assoc 20 (3): 299–304. PMID 15532931.
  12. ↑ http://www.aerzteblatt.de/archiv/143452/Insektenschutz-Wie-man-das-Stichrisiko-senkt
  13. ↑ http://www.pharmazeutische-zeitung.de/index.php?id=5363&type=0
  14. 1 2 Mishra AK, Singh N, Sharma VP, 1995 "Use of neem oil as a mosquito repellent in tribal villages of mandla district, madhya pradesh", Indian J Malariol, Sep;32(3):99-103 Pubmed
  15. ↑ "Test: Mosquito Repellents, The Verdict" Choice, The Australian Consumers Association
  16. 1 2 "Updated Information regarding Insect Repellents". Centers for Disease Control and Prevention. 8 May 2008.
  17. ↑ "Insect Repellent Use and Safety". West Nile Virus. Centers for Disease Control and Prevention. 12 January 2007.
  18. ↑ Carroll SP, Loye J, 2006, Journal of the American Mosquito Control Association 22(3):507-514, 510
  19. ↑ Jeong-Kyu KIM, Chang-Soo KANG, Jong-Kwon LEE, Young-Ran KIM, Hye-Yun HAN, Hwa Kyung YUN, Evaluation of Repellency Effect of Two Natural Aroma Mosquito Repellent Compounds, Citronella and Citronellal, Entomological Research 35 (2), 117–120, 2005
  20. ↑ Ibrahim Jantan, and Zaridah Mohd. Zaki, Development of environment-friendly insect repellents from the leaf oils of selected Malaysian plants, ASEAN Review of Biodiversity and Environmental Conservation (ARBEC), May 1998.
  21. ↑ Trongtokit Y, Rongsriyan Y, Komalamisra N, Apiwathnasom L, Comparative repellency of 38 essential oils against mosquito bites, Phytother Res. 2005 Apr;19(4):303-9
  22. ↑ "Are Mosquito Repellents active against the Zika virus ?".
  23. ↑ "Mosquito repellents that emit high-pitched sounds don't prevent bites" (Press release). Eurekalert!. April 17, 2007.
  24. ↑ "Health Advisory: Tick and Insect Repellents", Information factsheet, Department of Health, New York State
  25. ↑ "Reregistration Eligibility Decision: DEET." U.S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances. September 1998. pp39-40
  26. ↑ Deet
  27. ↑ Re-evaluation of Citronella Oil and Related Active Compounds for Use as Personal Insect Repellents (PDF). Responsible Pesticide Use (Pest Management Regulatory Agency (Canada)). 17 September 2004. ISBN 978-0-662-38012-2. Archived from the original (PDF) on 2008-07-11.
  28. ↑ "So Then: Who’s Afraid of Citronella Oil? Update!" Cropwatch Newsletter Vol 2,Issue 1, No. 1
  29. ↑ "Directive 98/8/EC of the European Parliament and of the Council of 16 February 1998 concerning the placing of biocidal products on the market". Official Journal of the European Communities. 16 February 1998. Retrieved 1 July 2011.
  30. 1 2 3 4 5 "Natural Mosquito Repellents - Which Natural Mosquito Repellents Work Best?". altmedicine.about.com. Retrieved 2008-08-05.
  31. ↑ Taverne, Janice (2001). "Malaria on the Web and the mosquito-repellent properties of basil". Trends in Parasitology 17 (6): 299–300. doi:10.1016/S1471-4922(01)01978-X.
  32. ↑ "A Granddad's Advice May Help Thwart Mosquitoes". www.sciencedaily.com. Retrieved 2008-08-05.
  33. ↑ A. Maxwell P. Jones, Jerome A. Klun, Charles L. Cantrell, Diane Ragone, Kamlesh R. Chauhan, Paula N. Brown , and Susan J. Murch (2012). "Isolation and Identification of Mosquito (Aedes aegypti) Biting Deterrent Fatty Acids from Male Inflorescences of Breadfruit (Artocarpus altilis (Parkinson) Fosberg)" 60 (15): 3867–3873. doi:10.1021/jf300101w.
  34. ↑ "Camphor (white)". www.aromatherapy-oil.co.uk. Retrieved 2008-08-05.
  35. 1 2 3 4 5 6 7 "Natural Mosquito Repellents". chemistry.about.com. Retrieved 2008-08-05.
  36. ↑ "Catnip Repels Mosquitoes More Effectively Than DEET". www.sciencedaily.com. Retrieved 2008-08-05.
  37. ↑ Tuetun, B.; Choochote, W.; Pongpaibul, Y.; Junkum, A.; Kanjanapothi, D.; Chaithong, U.; Jitpakdi, A.; Riyong, D.; Wannasan, A.; Pitasawat, B. (2008). "Field evaluation of G10, a celery (Apium graveolens)-based topical repellent, against mosquitoes (Diptera: Culicidae) in Chiang Mai province, northern Thailand". Parasitology Research 104 (3): 515–521. doi:10.1007/s00436-008-1224-9. PMID 18853188.
  38. ↑ Beck, Leslie. "Cinnamon — December 2006's Featured Food". Retrieved 2007-05-01.
  39. ↑ "Cinnamon Oil Kills Mosquitoes". www.sciencedaily.com. Retrieved 2008-08-05.
  40. 1 2 "Natural Insect and Rodent Repellents - Quick & Simple". www.quickandsimple.com. Retrieved 2009-01-02.
  41. ↑ Rahman, G. K. M. M.; N. Motoyama (1998). "Identification of the active components of garlic causing repellent effect against the rice weevil and the wheat flour beetle". Nihon Oyo Doubutsu Konchu Gakkai Taikai Koen Youshi 42: 211. Retrieved 22 November 2007.
  42. ↑ Botha, B. M.; C. M. McCrindle (2000). "An appropriate method for extracting the insect repellent citronellol from an indigenous plant (Pelargonium graveolens L'Her) for potential use by resource-limited animal owners". Retrieved 30 May 2009.
  43. ↑ Jaenson, Thomas G. T.; et al. (2006). "Repellency of Oils of Lemon Eucalyptus, Geranium, and Lavender and the Mosquito Repellent MyggA Natural to Ixodes ricinus (Acari: Ixodidae) in the Laboratory and Field". Journal of Medical Entomology 43 (4): 731–736. doi:10.1603/0022-2585(2006)43[731:ROOOLE]2.0.CO;2. ISSN 0022-2585.
  44. ↑ Cook, Samantha M.; et al. (2007). "Responses of Phradis parasitoids to volatiles of lavender, Lavendula angustifolia —a possible repellent for their host, Meligethes aeneus". BioControl (Springer) 52 (5): 591–598. doi:10.1007/s10526-006-9057-x.
  45. ↑ Oyedele, A.O.; et al. (2002). "Formulation of an effective mosquito-repellent topical product from Lemongrass oil". Phytomedicine 9 (3): 259–262. doi:10.1078/0944-7113-00120.
  46. 1 2 Momen, F. M.; et al. (2001). "Repellent and Oviposition-Deterring Activity of Rosemary and Sweet Marjoram on the Spider Mites Tetranychus urticae and Eutetranychus orientalis (Acari: Tetranychidae)". Acta Phytopathologica et Entomologica Hungarica (Akadémiai Kiadó) 36 (1 – 2): 155–164. doi:10.1556/APhyt.36.2001.1-2.18.
  47. 1 2 "Warnings". bitsandbrew.com. Archived from the original on April 23, 2008. Retrieved 2009-01-02.
  48. ↑ Ansari, M. A.; et al. (2000). "Larvicidal and mosquito repellent action of peppermint (Mentha piperita) oil". Bioresource Technology 71 (3): 267–271. doi:10.1016/S0960-8524(99)00079-6.
  49. ↑ Deka, M. K.; et al. "Antifeedant and Repellent Effects of Pongam (Pongamia Pinnata) and Wild Sage (Lantana Camara) on Tea Mosquito Bug (Helopeltis Theivora)". Indian Journal of Agricultural Science 68 (5): 274. Retrieved 22 November 2007.
  50. ↑ U.S. Patent 5,738,863
  51. ↑ "Common Weed, Ayurvedic Nightshade, Deadly For Dengue Mosquito". www.sciencedaily.com. Retrieved 2008-08-05.
  52. ↑ Govindarajan M, Sivakumar R. " Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae).Parasitol Res. 2011 Oct 20.
  53. ↑ http://www.homs.com/NEJM.pdf
  54. ↑ "Catnip Drives Cats Wild, But Drives Mosquitoes Away". Iowa State University. 27 August 2001. Retrieved 1 July 2011.
  55. ↑ http://www.homs.com/Johns%20Hopkins%20Report.pdf
  56. ↑ http://www.homs.com/ERAP-%20West%20Nile%20Virus%20-%20Cornell%20University%20Center%20for%20the%20Environment.pdf
  57. ↑ Lindsay, L.R.; Surgeoner, G.A.; Heal, J.D.; Gallivan, G.J. (June 1996). "Evaluation of the efficacy of 3% citronella candles and 5% citronella incense for protection against field populations of Aedes mosquitoes". Journal of the American Mosquito Control Association 12 (2): 293–294. PMID 8827606.
  58. ↑ BMJ Clinical Evidence
  59. 1 2 Ives A.R.; Paskewitz, S.M. (June 2005). "Testing vitamin B as a home remedy against mosquitoes". J. Am. Mosq. Control. Assoc. 21 (2): 213–217. doi:10.2987/8756-971X(2005)21[213:TVBAAH]2.0.CO;2. PMID 16033124.
  60. ↑ Khan AA, Maibach HI, Strauss WG, Fenley WR. (2005). "Vitamin B1 is not a systemic mosquito repellent in man". Trans. St. Johns Hosp. Dermatol. Soc. 55 (1): 99–102. PMID 4389912.
  61. ↑ Strauss WG, Maibach HI, Khan AA (1968). "Drugs and disease as mosquito repellents in man". Am. J. Trop. Med. Hyg. 17 (3): 461–464. PMID 4385133.
  62. ↑ Medscape: Medscape Access
  63. ↑ "Insect Repellents". DermNet NZ. 5 July 2010. Retrieved 1 July 2011.
  64. ↑ Lentek International-08/28/02
  65. ↑ "The great mosquito sting". Daily Mail (London). 6 September 2005. Retrieved 2010-11-27.
  66. ↑ Enayati AA, Hemingway J, Garner P., “Electronic mosquito repellents for preventing mosquito bites and malaria infection”, Cochrane Database Syst Rev., 2007 18; CD005434

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