Iobitridol

Iobitridol
Systematic (IUPAC) name

1-N,3-N-bis(2,3-dihydroxypropyl)-5-[3-hydroxy-2-(hydroxymethyl)propanamido]-2,4,6-triiodo-1-N,3-N-dimethylbenzene-1,3-dicarboxamide
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	136949-58-1^Y
ATC code	V08AB11 (WHO)
PubChem	CID 65985
ChemSpider	59379^N
UNII	182ECH14UH^Y
KEGG	D01181^Y
ChEBI	CHEBI:31701^N
ChEMBL	CHEMBL2107212
Chemical data
Formula	C₂₀H₂₈I₃N₃O₉
Molar mass	835.16 g/mol
SMILES CN(CC(CO)O)C(=O)c1c(c(c(c(c1I)NC(=O)C(CO)CO)I)C(=O)N(C)CC(CO)O)I
InChI InChI=1S/C20H28I3N3O9/c1-25(3-10(31)7-29)19(34)12-14(21)13(20(35)26(2)4-11(32)8-30)16(23)17(15(12)22)24-18(33)9(5-27)6-28/h9-11,27-32H,3-8H2,1-2H3,(H,24,33)^N Key:YLPBXIKWXNRACS-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Iobitridol is a molecule used as a contrast medium in X-ray imaging. 45.6% of the molecular mass is contributed by the three iodine atoms.

Xenetix 300 of Guerbet (Roissy, France) contains Iobitridol in 300 mg iodine/ml concentration. Recommended mean doses are 1.1 to 2.8 ml/kg body mass corresponding to 0,33 to 0,84 g iodine/kg human body mass. Injected into veins it will be filtered out by the kidneys. It is used also to fill joints or the uterus.

Iobitridol is nonionic but water-soluble by some -OH- groups.

Contrast media (V08)

X-ray and CT

Iodinated,
Water soluble

Nephrotropic, high osmolar	Diatrizoic acid^# Metrizoic acid Iodamide Iotalamic acid Ioxitalamic acid Ioglicic acid Acetrizoic acid Iocarmic acid Methiodal Diodone

Nephrotropic, low osmolar	Metrizamide Iohexol^# Ioxaglic acid Iopamidol Iopromide Iotrolan Ioversol Iopentol Iodixanol Iomeprol Iobitridol Ioxilan

Hepatotropic	Iodoxamic acid Iotroxic acid Ioglycamic acid Adipiodone Iobenzamic acid Iopanoic acid Iocetamic acid Sodium iopodate Tyropanoic acid Calcium iopodate

Iodinated,
Water insoluble

Non-iodinated

Barium sulfate^#

MRI

Paramagnetic	Gadolinium-based: Gadobenic acid Gadobutrol Gadodiamide Gadofosveset Gadolinium Gadopentetic acid Gadoteric acid Gadoteridol Gadoversetamide Gadoxetic acid Other: Ferric ammonium citrate Mangafodipir

Superparamagnetic	Ferumoxsil Ferristene Iron oxide, nanoparticles

Other	Perflubron

Ultrasound

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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