Jumping translocation breakpoint

Jumping translocation breakpoint
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KJX​
Identifiers
Symbols	JTB ; HJTB; HSPC222; PAR; hJT
External IDs	OMIM: 604671 MGI: 1346082 HomoloGene: 4870 GeneCards: JTB Gene
Gene ontology Molecular function • protein kinase binding Cellular component • cytoplasm • mitochondrion • centrosome • spindle • integral component of plasma membrane • membrane • midbody Biological process • cytokinesis • mitotic nuclear division • apoptotic mitochondrial changes • regulation of cell proliferation • positive regulation of protein kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10899	23922
Ensembl	ENSG00000143543	ENSMUSG00000027937
UniProt	O76095	O88824
RefSeq (mRNA)	NM_006694	NM_206924
RefSeq (protein)	NP_006685	NP_996807
Location (UCSC)	Chr 1: 153.97 – 153.98 Mb	Chr 3: 90.23 – 90.24 Mb
PubMed search

Jumping translocation breakpoint protein (JTB)
Identifiers
Symbol	JTB
Pfam	PF05439
InterPro	IPR008657
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The jumping translocation breakpoint protein (JTB), also knwon as prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene.^[1][2] It is an orphan receptor with unknown function.^[3]

The JTB family of proteins contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain. hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC).^[1] JTB has also been implicated in prostatic carcinomas.^[4]

References

1. Hatakeyama S, Osawa M, Omine M, Ishikawa F (Jun 1999). "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation". Oncogene 18 (12): 2085–90. doi:10.1038/sj.onc.1202510. PMID 10321732.
2. "Entrez Gene: JTB jumping translocation breakpoint".
3. Rousseau, Francois; Pan, Borlan; Fairbrother, Wayne J.; Bazan, J. Fernando; Lingel, Andreas (January 2012). "The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold". Journal of Molecular Biology 415 (1): 22–28. doi:10.1016/j.jmb.2011.10.048.
4. Platica O, Chen S, Ivan E, Lopingco MC, Holland JF, Platica M (May 2000). "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. doi:10.3892/ijo.16.5.1055. PMID 10762645.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wong N, Chan A, Lee SW, et al. (2003). "Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression". J. Hepatol. 38 (3): 298–306. doi:10.1016/S0168-8278(02)00412-9. PMID 12586295.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Platica O, Chen S, Ivan E, et al. (2000). "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. doi:10.3892/ijo.16.5.1055. PMID 10762645.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

This article incorporates text from the public domain Pfam and InterPro IPR008657