James Francis Tait

James Francis Tait was an English physicist and endocrinologist. He worked with his wife, Sylvia Agnes Sophia Tait from 1948 until her death in 2003,[1] a partnership described by the Oxford Dictionary of National Biography as “one of the most successful examples of husband-wife collaboration."[2] Together, they discovered and identified the hormone aldosterone.

Early life and education

Tait was born in Stockton on Tees in 1926,[3] the son of Herbert and Constance Tait (née Brotherton). His parents ran a small grocery shop, but his father died when he was 10.[4] He attended Darlington Queen Elizabeth 1 Grammar School, where he took Physics, Chemistry, Maths and English Literature for the Higher School Certificate. He went to Leeds University to read Physics and graduated in 1945. He joined the research group of Professor Whiddington at Leeds. completing his PhD thesis entitled “The energy distribution of electrons in discharge tubes” in 1947.

Career

Tait joined the department of medical physics at the Middlesex Hospital Medical School, London, as a lecturer, where he started to work on adrenal steroids, building on work by Ralph Dorfman. They went on to discover a previously unknown biologically active compound which they called electrocortin (later renamed aldosterone) in collaboration with Swiss chemist Tadeus Reichstein who had received the Nobel Prize for similar work on cortisol. The discovery was published in 1952.

In 1958, the Taits moved to the Worcester Foundation for Experimental Biology in the USA, where they worked with Gregory Pincus.[4] Tait developed mathematical methods to calculate hormone secretion rates from changes in the ratio of radioactively labelled to unlabelled hormone in urine. This developed into a new field of study – hormone dynamics.

Tait undertook periods of study leave at the Physiology Department at the University of Melbourne in Australia and at the Howard Florey Institute. Following the death of Gregory Pincus, he became joint chairman of the scientific council of the Worcester Foundation. In 1970, the Taits returned to the Middlesex Hospital as joint heads of the Biophysical Endocrinology Unit. Tait was also Joel Professor of Physics as Applied to Medicine. They worked on adrenal zona glomerulosa cells.

The Taits retired in 1982 and moved to East Boldre in the New Forest where they continued their scientific research using two apple IIe computers running in parallel. In 2003, a scientific meeting was organised in London to celebrate the 50th anniversary of the discovery of Aldosterone but Sylvia died shortly beforehand and Tait was being treated for diabetes in the Royal Bournemouth Hospital. He subsequently moved to Harrogate and continued his scientific interests and writing. He authored or co-authored over 150 scientific papers during his career.

Tait died in Harrogate hospital on 2 February 2014.[4]

Awards and honours

References

  1. ↑ Derek A Denton; I MacIntyre (1 December 2006). "Sylvia Agnes Sophia Tait". Biographical Memoirs of the Royal Society (The Royal Society publishing) 52: 379–399.
  2. ↑ "Sylvia Tait". Oxford Dictionary of National Biography. Retrieved 11 April 2016.
  3. ↑ " "Register of Births". Ancestry.co.uk. Retrieved 11 April 2016.
  4. 1 2 3 "Obituary:Professor James F Tait: Scientist whose work on steroids helped medical research into heart disease and oral contraception". The Independent. 21 February 2014.
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