John Spence
John Spence may refer to:
- John S. Spence (1788–1880), American Senator from Maryland
- John C. H. Spence, Richard Snell Professor of Physics at Arizona State University
- John Spence (politician) (1920–1986), British Conservative MP 1970–1986
- John Spence (scientist) (1929–2013), Trinidadian botanist and politician
- John Spence (frogman) (1918–2013), American World War II veteran, first American combat frogman
- John Spence (musician) (1969–1987), founding member of the band No Doubt
- John Selby Spence (Catholic bishop) (1909–1973)
See also
- Jonathan Spence, British-born historian
- John Spence Community High School, a secondary school in Preston, Tyne and Wear, England
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