Jonathan Weissman

Jonathan S. Weissman
Nationality American
Fields

Biochemistry

Biophysics
Institutions

UCSF

HHMI
Alma mater Harvard University, MIT, Yale University
Doctoral advisor Peter Kim
Other academic advisors Arthur Horwich
Known for

Ribosome profiling

Protein folding
Notable awards

Jonathan S. Weissman is a Professor of Cellular & Molecular Pharmacology at the University of California, San Francisco. He has been affiliated with the Howard Hughes Medical Institute (HHMI) since 2000; first, as an Assistant Investigator (2000-2005) and, since 2005, as an Investigator.

Education

He earned his B.A. in Physics from Harvard College (1988) and his Ph.D. in Physics (1993) from MIT working with Peter Kim. There, he started his studies on protein folding examining Bovine pancreatic trypsin inhibitor (BPTI).[1]

He was a postdoctoral fellow at Yale University (1993-1996), where he worked with Arthur Horwich studying the mechanism of GroEL.[2][3]

Career

Weissman's research team studies how cells ensure that proteins fold into their correct shape, as well as the role of protein misfolding in disease and normal physiology. The team also develops experimental and analytical approaches for exploring the organizational principles of biological systems and globally monitoring protein translation through ribosome profiling. A broad goal of his work is to bridge large-scale approaches and in depth mechanistic investigations to reveal the information encoded within genomes.[4][5][6]

Weissman has been a member of the National Academy of Sciences since 2009.

References

  1. ↑ Hoffman, M (Sep 20, 1991). "Straightening out the protein folding puzzle.". Science 253 (5026): 1357–8. doi:10.1126/science.1896845. PMID 1896845.
  2. ↑ Weissman, JS; Hohl, CM; Kovalenko, O; Kashi, Y; Chen, S; Braig, K; Saibil, HR; Fenton, WA; Horwich, AL (Nov 17, 1995). "Mechanism of GroEL action: productive release of polypeptide from a sequestered position under GroES.". Cell 83 (4): 577–87. doi:10.1016/0092-8674(95)90098-5. PMID 7585961.
  3. ↑ Weissman, Jonathan S.; O'Shea, Erin K. (1 January 2009). "2004 Irving Sigal Young Investigator Award". Protein Science 13 (12): 3333–3335. doi:10.1110/ps.041134604.
  4. ↑ "New Technique Focuses on Transcription". HHMI. 20 January 2011. Retrieved 14 February 2013.
  5. ↑ Ingolia, Nicholas T.; Lareau, Liana F.; Weissman, Jonathan S. (1 November 2011). "Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes". Cell 147 (4): 789–802. doi:10.1016/j.cell.2011.10.002.
  6. ↑ "Jonathan S. Weissman". HHMI. Retrieved 14 February 2013.

External links


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