José Santiago
José Santiago may refer to:
- José Santiago (1950s pitcher), known as "Pantalones", (b. 1928), Puerto Rican pitcher in the Major Leagues from 1954-1956
- José Santiago (1960s pitcher), known as "Palillo", (b. 1940), Puerto Rican pitcher in the Major Leagues from 1963-1970
- José Santiago (2000s pitcher) (b. 1974), Puerto Rican pitcher in the Major Leagues from 1997-2005
- José Luis Santiago Vasconcelos (1957–2008), senior Mexican civil servant killed in an aviation accident
- José L. Santiago (b. 1960), Puerto Rican sergeant major in the United States Marine Corps
- Josian Santiago, José A. "Josian" Santiago Rivera, (b. 1957), Puerto Rican politician and mayor of Comerío
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