KATNB1

Katanin p80 (WD repeat containing) subunit B 1
Identifiers
Symbols KATNB1 ; KAT; LIS6
External IDs OMIM: 602703 MGI: 1921437 HomoloGene: 4302 GeneCards: KATNB1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10300 74187
Ensembl ENSG00000140854 ENSMUSG00000031787
UniProt Q9BVA0 Q8BG40
RefSeq (mRNA) NM_005886 NM_028805
RefSeq (protein) NP_005877 NP_083081
Location (UCSC) Chr 16:
57.74 – 57.76 Mb
Chr 8:
95.08 – 95.1 Mb
PubMed search

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.[1][2]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.[2]

References

  1. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (May 1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719.
  2. 1 2 "Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1".

Further reading

External links

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