KCTD13

Potassium channel tetramerization domain containing 13
Identifiers
Symbols	KCTD13 ; BACURD1; FKSG86; PDIP1; POLDIP1; hBACURD1
External IDs	OMIM: 608947 MGI: 1923739 HomoloGene: 27800 GeneCards: KCTD13 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • GTP-Rho binding • protein domain specific binding • identical protein binding Cellular component • nucleus • nucleoplasm • Cul3-RING ubiquitin ligase complex Biological process • DNA replication • cell migration • protein ubiquitination • negative regulation of Rho protein signal transduction • stress fiber assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of DNA replication • protein homooligomerization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	253980	233877
Ensembl	ENSG00000174943	ENSMUSG00000030685
UniProt	Q8WZ19	Q8BGV7
RefSeq (mRNA)	NM_178863	NM_172747
RefSeq (protein)	NP_849194	NP_766335
Location (UCSC)	Chr 16: 29.91 – 29.93 Mb	Chr 7: 126.93 – 126.95 Mb
PubMed search

BTB/POZ domain-containing protein KCTD13 is a protein that in humans is encoded by the KCTD13 gene.^[1][2]

Interactions

KCTD13 has been shown to interact with PCNA.^[1]

Clinical relevance

Mutations in this gene have been associated to abnormalities in brain growth and behaviour.

References

1. He H, Tan CK, Downey KM, So AG (Oct 2001). "A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen". Proc Natl Acad Sci U S A 98 (21): 11979–84. doi:10.1073/pnas.221452098. PMC 59753. PMID 11593007.
2. "Entrez Gene: KCTD13 potassium channel tetramerisation domain containing 13".

Further reading

• Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Zhou J, Hu X, Xiong X, et al. (2005). "Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen". J. Exp. Zoolog. Part a Comp. Exp. Biol. 303 (3): 227–40. doi:10.1002/jez.a.150. PMID 15726626.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Tomaru T, Satoh T, Yoshino S, et al. (2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.