KDM2B

Lysine (K)-specific demethylase 2B
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4O64
Identifiers
Symbols	KDM2B ; CXXC2; FBXL10; Fbl10; JHDM1B; PCCX2
External IDs	OMIM: 609078 HomoloGene: 13069 IUPHAR: 2672 GeneCards: KDM2B Gene
EC number	1.14.11.27
Gene ontology Molecular function • DNA binding • protein binding • zinc ion binding • rRNA binding • histone demethylase activity • histone demethylase activity (H3-K36 specific) Cellular component • nucleus • nucleoplasm • nucleolus • PcG protein complex Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • transcription, DNA-templated • spermatogenesis • histone demethylation • midbrain-hindbrain boundary morphogenesis • fourth ventricle development • lateral ventricle development • third ventricle development • initiation of neural tube closure • forebrain development • midbrain development • hindbrain development • histone H2A monoubiquitination • negative regulation of neuron apoptotic process • embryonic camera-type eye morphogenesis • oxidation-reduction process • histone H3-K36 demethylation • negative regulation of neural precursor cell proliferation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84678	30841
Ensembl	ENSG00000089094	ENSMUSG00000029475
UniProt	Q8NHM5	Q6P1G2
RefSeq (mRNA)	NM_001005366	NM_001003953
RefSeq (protein)	NP_001005366	NP_001003953
Location (UCSC)	Chr 12: 121.43 – 121.58 Mb	Chr 5: 122.87 – 123.02 Mb
PubMed search

The human KDM2B gene encodes the protein Lysine (K)-specific demethylase 2B.^[1]

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.^[1]

References

1. "Entrez Gene: Lysine (K)-specific demethylase 2B".

Further reading

• Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (May 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochemical and Biophysical Research Communications 271 (2): 305–310. doi:10.1006/bbrc.2000.2614. PMID 10799292.
• Tzatsos A, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, Park PJ, Bardeesy N (Feb 2013). "KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs". The Journal of Clinical Investigation 123 (2): 727–739. doi:10.1172/JCI64535. PMC 3561797. PMID 23321669.
• Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN (Feb 2009). "Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus". Proceedings of the National Academy of Sciences of the United States of America 106 (8): 2641–2646. doi:10.1073/pnas.0813139106. PMC 2650317. PMID 19202064.
• Janzer A, Stamm K, Becker A, Zimmer A, Buettner R, Kirfel J (Sep 2012). "The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts". The Journal of Biological Chemistry 287 (37): 30984–30992. doi:10.1074/jbc.M112.341040. PMC 3438931. PMID 22825849.
• Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M (Nov 2007). "JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes". Nature 450 (7167): 309–313. doi:10.1038/nature06255. PMID 17994099.
• Koyama-Nasu R, David G, Tanese N (Sep 2007). "The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun". Nature Cell Biology 9 (9): 1074–1080. doi:10.1038/ncb1628. PMID 17704768.
• Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
• Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y (Feb 2006). "Histone demethylation by a family of JmjC domain-containing proteins". Nature 439 (7078): 811–816. doi:10.1038/nature04433. PMID 16362057.
• Ge R, Wang Z, Zeng Q, Xu X, Olumi AF (Jul 2011). "F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway". Cell Death and Differentiation 18 (7): 1184–1195. doi:10.1038/cdd.2010.185. PMC 3131965. PMID 21252908.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.