KDM6B

lysine (K)-specific demethylase 6B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XUE, 2XXZ, 4ASK, 5FP3
Identifiers
Aliases	KDM6B, JMJD3
External IDs	MGI: 2448492 HomoloGene: 18945 GeneCards: 23135
Gene ontology Molecular function • sequence-specific DNA binding • beta-catenin binding • chromatin binding • dioxygenase activity • metal ion binding • protein binding • oxidoreductase activity • histone demethylase activity (H3-K27 specific) Cellular component • nucleoplasm • cell nucleus Biological process • response to fungicide • histone demethylation • chromatin modification • cell fate commitment • histone H3-K27 demethylation • inflammatory response to antigenic stimulus • cardiac muscle cell differentiation • chromatin organization • response to activity • mesodermal cell differentiation • regulation of gene expression • endothelial cell differentiation • inflammatory response • hippocampus development • oxidation-reduction process • positive regulation of transcription from RNA polymerase II promoter • cellular response to hydrogen peroxide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23135	216850
Ensembl	ENSG00000132510	ENSMUSG00000018476
UniProt	O15054 I3L0Z0	Q5NCY0
RefSeq (mRNA)	XM_011523754 NM_001080424 XM_005256549 XM_005256550 XM_005256551 XM_005256552 XM_005256554 XM_006721483 XM_006721484 XM_011523750 XM_011523751 XM_011523752 XM_011523753	NM_001017426 XM_006532898 XM_011248919 XM_011248920 XM_011248921 XM_011248922 XM_011248923
RefSeq (protein)	NP_001073893.1 XP_005256606.1 XP_005256607.1 XP_005256608.1 XP_005256609.1 XP_005256611.1 XP_006721546.1 XP_011522052.1 XP_011522053.1 XP_011522054.1 XP_011522055.1	NP_001017426.1 XP_006532961.1 XP_011247221.1 XP_011247222.1 XP_011247223.1 XP_011247224.1 XP_011247225.1
Location (UCSC)	Chr 17: 7.84 – 7.85 Mb	Chr 11: 69.4 – 69.41 Mb
PubMed search
Wikidata

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Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene. ^[1]

References

1. "Entrez Gene: Lysine demethylase 6B". Retrieved 2016-04-09.

Further reading

• Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K (2007). "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development". Nature 449 (7163): 731–4. doi:10.1038/nature06145. PMID 17713478.