KDM7A

lysine (K)-specific demethylase 7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KV5, 3KV6, 3KV9, 3KVA, 3KVB, 3U78
Identifiers
Aliases	KDM7A, JHDM1D
External IDs	MGI: 2443388 HomoloGene: 25281 GeneCards: 80853
Gene ontology Molecular function • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors • iron ion binding • histone demethylase activity (H3-K9 specific) • histone demethylase activity (H4-K20 specific) • zinc ion binding • dioxygenase activity • metal ion binding • methylated histone binding • histone demethylase activity (H3-K36 specific) • oxidoreductase activity • histone demethylase activity (H3-K27 specific) Cellular component • nucleoplasm • nucleolus • cell nucleus Biological process • chromatin modification • regulation of transcription, DNA-templated • histone H3-K27 demethylation • histone H3-K9 demethylation • histone H4-K20 demethylation • chromatin organization • transcription, DNA-templated • nervous system development • positive regulation of transcription, DNA-templated • histone H3-K36 demethylation • oxidation-reduction process • midbrain development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80853	338523
Ensembl	ENSG00000006459	ENSMUSG00000042599
UniProt	Q6ZMT4	Q3UWM4
RefSeq (mRNA)	XM_011516587 NM_030647 XM_011516586	NM_001033430
RefSeq (protein)	NP_085150.1	NP_001028602.2
Location (UCSC)	Chr 7: 140.08 – 140.18 Mb	Chr 6: 39.14 – 39.21 Mb
PubMed search
Wikidata

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Lysine demethylase 7A is a protein that in humans is encoded by the KDM7A gene. ^[1]

References

1. "Entrez Gene: Lysine demethylase 7A". Retrieved 2016-04-09.

Further reading

• Huang C, Xiang Y, Wang Y, Li X, Xu L, Zhu Z, Zhang T, Zhu Q, Zhang K, Jing N, Chen CD (2010). "Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4". Cell Res. 20 (2): 154–65. doi:10.1038/cr.2010.5. PMID 20084082.