KIDINS220

Kinase D-interacting substrate, 220kDa
Identifiers
Symbols	KIDINS220 ; ARMS
External IDs	OMIM: 615759 MGI: 1924730 HomoloGene: 14254 GeneCards: KIDINS220 Gene
Gene ontology Molecular function • protein kinase regulator activity • PDZ domain binding Cellular component • nucleoplasm • late endosome • cytosol • membrane • integral component of membrane • protein complex Biological process • activation of MAPKK activity • in utero embryonic development • positive regulation of neuron projection development • cytoplasmic transport • nerve growth factor signaling pathway • regulation of protein kinase activity • neurotrophin TRK receptor signaling pathway • dendrite morphogenesis • cellular response to nerve growth factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57498	77480
Ensembl	ENSG00000134313	ENSMUSG00000036333
UniProt	Q9ULH0	E9Q9B7
RefSeq (mRNA)	NM_020738	NM_001081378
RefSeq (protein)	NP_065789	NP_001074847
Location (UCSC)	Chr 2: 8.73 – 8.84 Mb	Chr 12: 24.97 – 25.06 Mb
PubMed search

Kinase D-interacting substrate of 220 kDa is an enzyme that in humans is encoded by the KIDINS220 gene.^[1][2][3]

References

1. Iglesias T, Cabrera-Poch N, Mitchell MP, Naven TJ, Rozengurt E, Schiavo G (Jan 2001). "Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D". J Biol Chem 275 (51): 40048–56. doi:10.1074/jbc.M005261200. PMID 10998417.
2. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
3. "Entrez Gene: KIDINS220 kinase D-interacting substance of 220 kDa".

Further reading

• Kong H, Boulter J, Weber JL, et al. (2001). "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors.". J. Neurosci. 21 (1): 176–85. PMID 11150334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Riol-Blanco L, Iglesias T, Sánchez-Sánchez N, et al. (2004). "The neuronal protein Kidins220 localizes in a raft compartment at the leading edge of motile immature dendritic cells.". Eur. J. Immunol. 34 (1): 108–18. doi:10.1002/eji.200324640. PMID 14971036.
• Arévalo JC, Yano H, Teng KK, Chao MV (2004). "A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein.". EMBO J. 23 (12): 2358–68. doi:10.1038/sj.emboj.7600253. PMC 423292. PMID 15167895.
• Chang MS, Arevalo JC, Chao MV (2004). "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein.". J. Neurosci. Res. 78 (2): 186–92. doi:10.1002/jnr.20262. PMID 15378608.
• Bracale A, Cesca F, Neubrand VE, et al. (2007). "Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation.". Mol. Biol. Cell 18 (1): 142–52. doi:10.1091/mbc.E06-05-0453. PMC 1751333. PMID 17079733.