KIF14

Kinesin family member 14
Identifiers
Symbols	KIF14 ; MKS12
External IDs	OMIM: 611279 MGI: 1098226 HomoloGene: 8916 ChEMBL: 5576 GeneCards: KIF14 Gene
Gene ontology Molecular function • microtubule motor activity • protein binding • ATP binding • microtubule binding • ATP-dependent microtubule motor activity, plus-end-directed • tubulin binding • ATPase activity • protein kinase binding • PDZ domain binding Cellular component • nucleus • cytosol • kinesin complex • microtubule • plasma membrane • membrane • midbody • spindle midzone Biological process • regulation of cell growth • microtubule-based movement • microtubule depolymerization • mitotic metaphase plate congression • small GTPase mediated signal transduction • positive regulation of cell proliferation • regulation of G2/M transition of mitotic cell cycle • cerebellar granular layer structural organization • cerebellar Purkinje cell layer structural organization • cerebellar cortex development • hippocampus development • olfactory bulb development • cell proliferation in forebrain • cerebral cortex development • regulation of cell adhesion • regulation of cell migration • cytoskeleton-dependent intracellular transport • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • regulation of myelination • activation of protein kinase activity • positive regulation of cytokinesis • regulation of Rap protein signal transduction • negative regulation of integrin activation • substrate adhesion-dependent cell spreading • negative regulation of apoptotic process • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of neuron apoptotic process • negative regulation of neuron apoptotic process • establishment of protein localization • cell division • response to docetaxel trihydrate • mitotic cell cycle process • regulation of cell maturation • regulation of G1/S transition of mitotic cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9928	381293
Ensembl	ENSG00000118193	ENSMUSG00000041498
UniProt	Q15058	L0N7N1
RefSeq (mRNA)	NM_001305792	NM_001081258
RefSeq (protein)	NP_001292721	NP_001274108
Location (UCSC)	Chr 1: 200.55 – 200.62 Mb	Chr 1: 136.47 – 136.53 Mb
PubMed search

Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.^[1][2]

References

1. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
2. "Entrez Gene: KIF14 kinesin family member 14".

Further reading

• Nakagawa T, Tanaka Y, Matsuoka E, et al. (1997). "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9654–9. doi:10.1073/pnas.94.18.9654. PMC 23244. PMID 9275178.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Corson TW, Huang A, Tsao MS, Gallie BL (2005). "KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers.". Oncogene 24 (30): 4741–53. doi:10.1038/sj.onc.1208641. PMID 15897902.
• Gruneberg U, Neef R, Li X, et al. (2006). "KIF14 and citron kinase act together to promote efficient cytokinesis.". J. Cell Biol. 172 (3): 363–72. doi:10.1083/jcb.200511061. PMC 2063646. PMID 16431929.
• Corson TW, Gallie BL (2006). "KIF14 mRNA expression is a predictor of grade and outcome in breast cancer.". Int. J. Cancer 119 (5): 1088–94. doi:10.1002/ijc.21954. PMID 16570270.
• Carleton M, Mao M, Biery M, et al. (2006). "RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure.". Mol. Cell. Biol. 26 (10): 3853–63. doi:10.1128/MCB.26.10.3853-3863.2006. PMC 1488988. PMID 16648480.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Bowles E, Corson TW, Bayani J, et al. (2007). "Profiling genomic copy number changes in retinoblastoma beyond loss of RB1.". Genes Chromosomes Cancer 46 (2): 118–29. doi:10.1002/gcc.20383. PMID 17099872.
• Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells.". J. Proteome Res. 6 (1): 298–305. doi:10.1021/pr060438j. PMID 17203973.
• Corson TW, Zhu CQ, Lau SK, et al. (2007). "KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer.". Clin. Cancer Res. 13 (11): 3229–34. doi:10.1158/1078-0432.CCR-07-0393. PMID 17545527.
• Madhavan J, Coral K, Mallikarjuna K, et al. (2007). "High expression of KIF14 in retinoblastoma: association with older age at diagnosis.". Invest. Ophthalmol. Vis. Sci. 48 (11): 4901–6. doi:10.1167/iovs.07-0063. PMID 17962437.