KIF18A

Kinesin family member 18A
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3LRE​
Identifiers
Symbols	KIF18A ; MS-KIF18A; PPP1R99
External IDs	OMIM: 611271 MGI: 2446977 HomoloGene: 41820 GeneCards: KIF18A Gene
Gene ontology Molecular function • actin binding • protein binding • ATP binding • microtubule binding • ATP-dependent microtubule motor activity, plus-end-directed • ubiquitin binding • microtubule plus-end binding • tubulin-dependent ATPase activity Cellular component • ruffle • nucleus • cytoplasm • microtubule organizing center • kinetochore microtubule • cytosol • kinesin complex • caveola • microtubule cytoskeleton Biological process • mitotic sister chromatid segregation • mitotic cell cycle • microtubule-based movement • microtubule depolymerization • mitotic metaphase plate congression • small GTPase mediated signal transduction • blood coagulation • metabolic process • protein transport • antigen processing and presentation of exogenous peptide antigen via MHC class II Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81930	228421
Ensembl	ENSG00000121621	ENSMUSG00000027115
UniProt	Q8NI77	Q91WD7
RefSeq (mRNA)	NM_031217	NM_139303
RefSeq (protein)	NP_112494	NP_647464
Location (UCSC)	Chr 11: 28.02 – 28.11 Mb	Chr 2: 109.28 – 109.34 Mb
PubMed search

Kinesin-like protein KIF18A is a protein that in humans is encoded by the KIF18A gene.^[1][2]

References

1. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
2. "Entrez Gene: KIF18A kinesin family member 18A".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Luboshits G, Benayahu D (2005). "MS-KIF18A, new kinesin; structure and cellular expression.". Gene 351: 19–28. doi:10.1016/j.gene.2005.02.009. PMID 15878648.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Mayr MI, Hümmer S, Bormann J, et al. (2007). "The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression.". Curr. Biol. 17 (6): 488–98. doi:10.1016/j.cub.2007.02.036. PMID 17346968.