KIF22

Kinesin family member 22
Rendering based on PDB 2EDU​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EDU​, 3BFN​
Identifiers
Symbols	KIF22 ; A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2; SEMDJL2
External IDs	OMIM: 603213 MGI: 109233 HomoloGene: 32011 ChEMBL: 5470 GeneCards: KIF22 Gene
Gene ontology Molecular function • DNA binding • microtubule motor activity • ATP binding • microtubule binding • ATPase activity Cellular component • kinetochore • chromatin • nucleus • nucleoplasm • cytoplasm • spindle • cytosol • kinesin complex • microtubule • focal adhesion Biological process • DNA repair • microtubule-based movement • sister chromatid cohesion • mitotic nuclear division • mitotic metaphase plate congression • blood coagulation • antigen processing and presentation of exogenous peptide antigen via MHC class II Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3835	110033
Ensembl	ENSG00000079616	ENSMUSG00000030677
UniProt	Q14807	Q3V300
RefSeq (mRNA)	NM_001256269	NM_145588
RefSeq (protein)	NP_001243198	NP_663563
Location (UCSC)	Chr 16: 29.79 – 29.81 Mb	Chr 7: 127.03 – 127.04 Mb
PubMed search

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.^[1][2][3]

The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance.^[3]

Interactions

KIF22 has been shown to interact with SIAH1.^[4]

Clinical relevance

Mutations in this gene have been shown to cause developmental disorders such as Spondyloepimetaphyseal dysplasia with joint laxity.^[5]

References

1. Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T (April 1996). "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle". EMBO J 15 (3): 457–67. PMC 449964. PMID 8599929.
2. Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc Natl Acad Sci U S A 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
3. "Entrez Gene: KIF22 kinesin family member 22".
4. Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
5. Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ (December 2011). "Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type". Am. J. Hum. Genet. 89 (6): 760–6. doi:10.1016/j.ajhg.2011.10.015. PMC 3234366. PMID 22152677.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Zhang S, Nonoyama M (1994). "The cellular proteins that bind specifically to the Epstein-Barr virus origin of plasmid DNA replication belong to a gene family". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2843–7. doi:10.1073/pnas.91.7.2843. PMC 43467. PMID 8146198.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Song J, Murakami H, Tsutsui H, et al. (1998). "Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ)". J. Biol. Chem. 273 (32): 20603–14. doi:10.1074/jbc.273.32.20603. PMID 9685418.
• Song J, Murakami H, Yang ZQ, et al. (1998). "Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2". Genomics 52 (3): 374–7. doi:10.1006/geno.1998.5452. PMID 9790757.
• Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Funabiki H, Murray AW (2000). "The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement". Cell 102 (4): 411–24. doi:10.1016/S0092-8674(00)00047-7. PMID 10966104.
• Antonio C, Ferby I, Wilhelm H, et al. (2000). "Xkid, a chromokinesin required for chromosome alignment on the metaphase plate". Cell 102 (4): 425–35. doi:10.1016/S0092-8674(00)00048-9. PMID 10966105.
• Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
• Levesque AA, Compton DA (2001). "The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles". J. Cell Biol. 154 (6): 1135–46. doi:10.1083/jcb.200106093. PMC 2150818. PMID 11564754.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yajima J, Edamatsu M, Watai-Nishii J, et al. (2003). "The human chromokinesin Kid is a plus end-directed microtubule-based motor". EMBO J. 22 (5): 1067–74. doi:10.1093/emboj/cdg102. PMC 150335. PMID 12606572.
• Shiroguchi K, Ohsugi M, Edamatsu M, et al. (2003). "The second microtubule-binding site of monomeric kid enhances the microtubule affinity". J. Biol. Chem. 278 (25): 22460–5. doi:10.1074/jbc.M212274200. PMID 12692123.
• Ohsugi M, Tokai-Nishizumi N, Shiroguchi K, et al. (2003). "Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes". EMBO J. 22 (9): 2091–103. doi:10.1093/emboj/cdg208. PMC 156080. PMID 12727876.
• Venkatesh LK, Gettemeier T, Chinnadurai G (2003). "A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein". J. Virol. 77 (13): 7236–43. doi:10.1128/JVI.77.13.7236-7243.2003. PMC 164832. PMID 12805422.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tokai-Nishizumi N, Ohsugi M, Suzuki E, Yamamoto T (2006). "The chromokinesin Kid is required for maintenance of proper metaphase spindle size". Mol. Biol. Cell 16 (11): 5455–63. doi:10.1091/mbc.E05-03-0244. PMC 1266440. PMID 16176979.