KIFC1

Kinesin family member C1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2REP​
Identifiers
Symbols	KIFC1 ; HSET; KNSL2
External IDs	OMIM: 603763 MGI: 109596 HomoloGene: 83229 GeneCards: KIFC1 Gene
Gene ontology Molecular function • microtubule motor activity • ATP binding • microtubule binding • ATP-dependent microtubule motor activity, minus-end-directed Cellular component • nucleus • early endosome • microtubule organizing center • spindle • kinesin complex • microtubule • membrane Biological process • mitotic sister chromatid segregation • microtubule-based movement • mitotic metaphase plate congression • spermatogenesis • blood coagulation • metabolic process • cell division • mitotic spindle assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3833	16580
Ensembl	ENSG00000056678	ENSMUSG00000024301
UniProt	Q9BW19	Q9QWT9
RefSeq (mRNA)	NM_002263	NM_016761
RefSeq (protein)	NP_002254	NP_444403
Location (UCSC)	Chr 6: 33.39 – 33.41 Mb	Chr 17: 26.92 – 26.93 Mb
PubMed search

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.^[1][2]

Function

The protein KifC1 is a member of kinesin-14 family. KifC1 consists of C-terminal motor domain, superhelical stalk and N-terminal tail domain. Tail and motor domains contain microtubule-binding sites. This kinesin moves towards the minus-end of microtubule and has an ability to slide or crosslink microtubules. KifC1 functions during mitotic spindle formation.

References

1. Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T, Yokoyama K, Soeda E, Ikemura T, Abe K (Feb 1994). "Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region". Immunogenetics 39 (3): 194–200. doi:10.1007/bf00241260. PMID 8276466.
2. "Entrez Gene: KIFC1 kinesin family member C1".

Further reading

• Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
• Janitz K, Wild A, Beck S, Savasta S, Beluffi G, Ziegler A, Volz A (1999). "Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS)". Immunogenetics 49 (7–8): 644–52. doi:10.1007/s002510050660. PMID 10369922.
• Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis". J. Cell Biol. 162 (5): 863–75. doi:10.1083/jcb.200306009. PMC 2172827. PMID 12939256.
• Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–72. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Al-Bassam J, Roger B, Halpain S, Milligan RA (2007). "Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c". Cell Motil. Cytoskeleton 64 (5): 377–89. doi:10.1002/cm.20190. PMID 17326138.