KIRREL2
| Kin of IRRE like 2 (Drosophila) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | KIRREL2 ; FILTRIN; NEPH3; NLG1 | ||||||||||||
| External IDs | OMIM: 607762 MGI: 2442334 HomoloGene: 35249 GeneCards: KIRREL2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 84063 | 243911 | |||||||||||
| Ensembl | ENSG00000126259 | ENSMUSG00000036915 | |||||||||||
| UniProt | Q6UWL6 | Q7TSU7 | |||||||||||
| RefSeq (mRNA) | NM_032123 | NM_172898 | |||||||||||
| RefSeq (protein) | NP_115499 | NP_766486 | |||||||||||
| Location (UCSC) |
Chr 19: 35.86 – 35.87 Mb |
Chr 7: 30.45 – 30.46 Mb | |||||||||||
| PubMed search | |||||||||||||
Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene.[1][2][3] It is primarily expressed in β cells of the pancreatic islets.[1]
KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3). NEPH proteins bind the
References
- 1 2 Sun C, Kilburn D, Lukashin A, Crowell T, Gardner H, Brundiers R, Diefenbach B, Carulli JP (Jul 2003). "Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets". Genomics 82 (2): 130–42. doi:10.1016/S0888-7543(03)00110-1. PMID 12837264.
- ↑ Ihalmo P, Palmen T, Ahola H, Valtonen E, Holthofer H (Dec 2002). "Filtrin is a novel member of nephrin-like proteins". Biochem Biophys Res Commun 300 (2): 364–70. doi:10.1016/S0006-291X(02)02854-1. PMID 12504092.
- ↑ "Entrez Gene: KIRREL2 kin of IRRE like 2 (Drosophila)".
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rinta-Valkama J, Aaltonen P, Lassila M, et al. (2007). "Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes.". Diabetes Metab. Res. Rev. 23 (2): 119–26. doi:10.1002/dmrr.655. PMID 16741999.
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