KLHDC3

Kelch domain containing 3
Identifiers
Symbols KLHDC3 ; PEAS; dJ20C7.3
External IDs OMIM: 611248 MGI: 2651568 HomoloGene: 14290 GeneCards: KLHDC3 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 116138 71765
Ensembl ENSG00000124702 ENSMUSG00000063576
UniProt Q9BQ90 Q8VEM9
RefSeq (mRNA) NM_001242872 NM_001163729
RefSeq (protein) NP_476502 NP_001157201
Location (UCSC) Chr 6:
43.01 – 43.02 Mb
Chr 17:
46.67 – 46.68 Mb
PubMed search

Kelch domain-containing protein 3 is a protein that in humans is encoded by the KLHDC3 gene.[1][2]

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasm and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination.[2]

References

  1. Ohinata Y, Sutou S, Kondo M, Takahashi T, Mitsui Y (Nov 2002). "Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis". Biol Reprod 67 (6): 1824–31. doi:10.1095/biolreprod.101.002550. PMID 12444059.
  2. 1 2 "Entrez Gene: KLHDC3 kelch domain containing 3".

Further reading


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