KLHL2

Kelch-like family member 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2XN4, 4CHB
Identifiers
Symbols	KLHL2 ; ABP-KELCH; MAV; MAYVEN
External IDs	OMIM: 605774 HomoloGene: 21416 GeneCards: KLHL2 Gene
Gene ontology Molecular function • actin binding • protein binding Cellular component • ruffle • cytoplasm • cytosol • actin cytoskeleton • lamellipodium • Cul3-RING ubiquitin ligase complex Biological process • protein ubiquitination Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11275	77113
Ensembl	ENSG00000109466	ENSMUSG00000031605
UniProt	O95198	Q8JZP3
RefSeq (mRNA)	NM_001161521	NM_178633
RefSeq (protein)	NP_001154993	NP_848748
Location (UCSC)	Chr 4: 165.21 – 165.32 Mb	Chr 8: 64.74 – 64.85 Mb
PubMed search

Kelch-like family member 2 is a protein that in humans is encoded by the KLHL2 gene.^[1]

References

1. "Entrez Gene: Kelch-like family member 2".

Further Reading

• Tseng LA, Bixby JL (Aug 2011). "Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis". Molecular and Cellular Neurosciences 47 (4): 254–64. doi:10.1016/j.mcn.2011.04.005. PMID 21549840.
• Korutla L, Wang P, Jackson TG, Mackler SA. "NAC1, a POZ/BTB protein that functions as a corepressor". Neurochemistry International 54 (3-4): 245–52. doi:10.1016/j.neuint.2008.12.008. PMID 19121354.
• Williams SK, Spence HJ, Rodgers RR, Ozanne BW, Fitzgerald U, Barnett SC (Sep 2005). "Role of Mayven, a kelch-related protein in oligodendrocyte process formation". Journal of Neuroscience Research 81 (5): 622–31. doi:10.1002/jnr.20588. PMID 16035103.
• Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS. "Update on the Kelch-like (KLHL) gene family". Human Genomics 7: 13. doi:10.1186/1479-7364-7-13. PMID 23676014.
• Mai A, Jung SK, Yonehara S (Oct 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research 300 (1): 72–83. doi:10.1016/j.yexcr.2004.06.023. PMID 15383316.
• Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T (Jun 2014). "Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation". The Biochemical Journal 460 (2): 237–46. doi:10.1042/BJ20140153. PMID 24641320.
• Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S (Jul 1999). "Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain". Molecular Biology of the Cell 10 (7): 2361–75. doi:10.1091/mbc.10.7.2361. PMID 10397770.
• Bu X, Avraham HK, Li X, Lim B, Jiang S, Fu Y, Pestell RG, Avraham S (Mar 2005). "Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells". Oncogene 24 (14): 2398–409. doi:10.1038/sj.onc.1208466. PMID 15735724.
• Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S (Aug 2013). "KLHL2 interacts with and ubiquitinates WNK kinases". Biochemical and Biophysical Research Communications 437 (3): 457–62. doi:10.1016/j.bbrc.2013.06.104. PMID 23838290.