KLHL3

Kelch-like family member 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4CH9, 4HXI
Identifiers
Symbols	KLHL3 ; PHA2D
External IDs	OMIM: 605775 HomoloGene: 79542 GeneCards: KLHL3 Gene
Gene ontology Molecular function • actin binding • structural molecule activity • protein binding Cellular component • cytosol • cytoskeleton • Cul3-RING ubiquitin ligase complex Biological process • protein ubiquitination • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • ion homeostasis • renal sodium ion absorption • protein K48-linked ubiquitination • distal tubule morphogenesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26249	100503085
Ensembl	ENSG00000146021	ENSMUSG00000014164
UniProt	Q9UH77	E0CZ16
RefSeq (mRNA)	NM_001257194	NM_001195075
RefSeq (protein)	NP_001244123	NP_001182004
Location (UCSC)	Chr 5: 137.62 – 137.74 Mb	Chr 13: 58 – 58.11 Mb
PubMed search

Kelch-like protein 3 is a protein in humans that is encoded by the KLHL3 gene.^[1] Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Function

This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex.^[1]

Clinical significance

Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia^[2] and metabolic acidosis.^[1]

References

1. "Entrez Gene: Kelch-like 3 (Drosophila)". Retrieved 2012-04-26.
2. "KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron.". Nature Genetics 44 (5): 609. Apr 26, 2012. doi:10.1038/ng0512-609. PMID 22538725.

Further reading

• Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Oct 1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Yeo A, Samways DS, Fowler CE, Gunn-Moore F, Henderson G (Mar 2001). "Coincident signalling between the Gi/Go-coupled delta-opioid receptor and the Gq-coupled m3 muscarinic receptor at the level of intracellular free calcium in SH-SY5Y cells". Journal of Neurochemistry 76 (6): 1688–700. doi:10.1046/j.1471-4159.2001.00185.x. PMID 11259487.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Lai F, Orelli BJ, Till BG, Godley LA, Fernald AA, Pamintuan L, Le Beau MM (May 2000). "Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene". Genomics 66 (1): 65–75. doi:10.1006/geno.2000.6181. PMID 10843806.