KLRG1

Killer cell lectin-like receptor subfamily G, member 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3FF7​
Identifiers
Symbols	KLRG1 ; 2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L; MAFA-LIKE
External IDs	OMIM: 604874 MGI: 1355294 HomoloGene: 4244 GeneCards: KLRG1 Gene
Gene ontology Molecular function • receptor activity • protein binding • carbohydrate binding Cellular component • plasma membrane • integral component of membrane Biological process • inflammatory response • cellular defense response • cell surface receptor signaling pathway • innate immune response • regulation of immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10219	50928
Ensembl	ENSG00000139187	ENSMUSG00000030114
UniProt	Q96E93	O88713
RefSeq (mRNA)	NM_005810	NM_016970
RefSeq (protein)	NP_005801	NP_058666
Location (UCSC)	Chr 12: 8.95 – 9.01 Mb	Chr 6: 122.27 – 122.28 Mb
PubMed search

Killer cell lectin-like receptor subfamily G member 1 is a protein that in humans is encoded by the KLRG1 gene.^{[1][2][3][4][5]}

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined.^[5]

References

1. Hanke T, Corral L, Vance RE, Raulet DH (Jan 1999). "2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells". Eur J Immunol 28 (12): 4409–17. doi:10.1002/(SICI)1521-4141(199812)28:12<4409::AID-IMMU4409>3.0.CO;2-3. PMID 9862378.
2. Butcher S, Arney KL, Cook GP (Dec 1998). "MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells". Eur J Immunol 28 (11): 3755–62. doi:10.1002/(SICI)1521-4141(199811)28:11<3755::AID-IMMU3755>3.0.CO;2-3. PMID 9842918.
3. Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N (Feb 2006). "Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity". J Exp Med 203 (2): 289–95. doi:10.1084/jem.20051986. PMC 2118217. PMID 16461340.
4. Thimme R, Appay V, Koschella M, Panther E, Roth E, Hislop AD, Rickinson AB, Rowland-Jones SL, Blum HE, Pircher H (Sep 2005). "Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation". J Virol 79 (18): 12112–6. doi:10.1128/JVI.79.18.12112-12116.2005. PMC 1212638. PMID 16140789.
5. "Entrez Gene: KLRG1 killer cell lectin-like receptor subfamily G, member 1".

Further reading

• Ortega E, Schneider H, Pecht I (1991). "Possible interactions between the Fc epsilon receptor and a novel mast cell function-associated antigen". Int. Immunol. 3 (4): 333–42. doi:10.1093/intimm/3.4.333. PMID 1831652.
• Lamers MB, Lamont AG, Williams DH (1998). "Human MAFA has alternatively spliced variants". Biochim. Biophys. Acta 1399 (2–3): 209–12. doi:10.1016/s0167-4781(98)00107-9. PMID 9765598.
• Voehringer D, Koschella M, Pircher H (2003). "Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)". Blood 100 (10): 3698–702. doi:10.1182/blood-2002-02-0657. PMID 12393723.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuoka TA, Artner I, Henderson E, et al. (2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2930–3. doi:10.1073/pnas.0306233101. PMC 365722. PMID 14973194.
• Marcolino I, Przybylski GK, Koschella M, et al. (2004). "Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history". Eur. J. Immunol. 34 (10): 2672–80. doi:10.1002/eji.200425282. PMID 15368283.
• Ibegbu CC, Xu YX, Harris W, et al. (2005). "Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57". J. Immunol. 174 (10): 6088–94. doi:10.4049/jimmunol.174.10.6088. PMID 15879103.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Bengsch B, Spangenberg HC, Kersting N, et al. (2007). "Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver". J. Virol. 81 (2): 945–53. doi:10.1128/JVI.01354-06. PMC 1797464. PMID 17079288.
• Schwartzkopff S, Gründemann C, Schweier O, et al. (2007). "Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans". J. Immunol. 179 (2): 1022–9. doi:10.4049/jimmunol.179.2.1022. PMID 17617594.

External links

• KLRG1 human gene location in the UCSC Genome Browser.
• KLRG1 human gene details in the UCSC Genome Browser.