Kallikrein 13

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Kallikrein 13 (EC 3.4.21.119, KLK13, kallikrein mK13, mGK-13, mK13, mKLK13, prorenin converting enzyme 1, PRECE-1, prorenin-converting enzyme, PRECE, proteinase P) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg- pair in the N-terminus, to yield mature renin

This enzyme belongs in peptidase family S1A.

References

↑ Nakayama, K., Kim, W.S., Nakagawa, T., Nagahama, M. and Murakami, K. (1990). "Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis". J. Biol. Chem. 265: 21027–21031. PMID 2250008.
↑ Kim, W.S., Hatsuzawa, K., Ishizuka, Y., Hashiba, K., Murakami, K. and Nakayama, K. (1990). "A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization". J. Biol. Chem. 265: 5930–5933. PMID 2180937.
↑ Kikkawa, Y., Yamanaka, N., Tada, J., Kanamori, N., Tsumura, K. and Hosoi, K. (1998). "Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22)". Biochim. Biophys. Acta 1382: 55–64. doi:10.1016/s0167-4838(97)00144-1. PMID 9507064.
↑ Yao, C., Karabasil, M.R., Purwanti, N., Li, X., Akamatsu, T., Kanamori, N. and Hosoi, K. (2006). "Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1β in the submandibular gland of mice". J. Biol. Chem. 281: 7968–7976. doi:10.1074/jbc.m507705200. PMID 16423834.

External links

Kallikrein 13 at the US National Library of Medicine Medical Subject Headings (MeSH)

Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)

Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic

Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator

Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase

Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin

Venombin	Ancrod Batroxobin

Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin Streptokinase S1P Cathepsin A G

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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