Kallikrein 8

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Kallikrein 8 (EC 3.4.21.118, KLK8, PRSS19, human kallikrein 8, hK8, mK8, ovasin, tumor-associated differentially expressed gene 14, TADG-14, NP, neuropsin) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

The enzyme is activated by removal of an N-terminal prepropeptide.

References

↑ Chen, Z.L., Yoshida, S., Kato, K., Momota, Y., Suzuki, J., Tanaka, T., Ito, J., Nishino, H., Aimoto, S., Kiyama, H. and Shiosaka, S. (1995). "Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus". J. Neurosci. 15 (7 Pt 2): 5088–5097. PMID 7623137.
↑ Shimizu, C., Yoshida, S., Shibata, M., Kato, K., Momota, Y., Matsumoto, K., Shiosaka, T., Midorikawa, R., Kamachi, T., Kawabe, A. and Shiosaka, S. (1998). "Characterization of recombinant and brain neuropsin, a plasticity-related serine protease". J. Biol. Chem. 273 (18): 11189–11196. doi:10.1074/jbc.273.18.11189. PMID 9556608.
↑ Rajapakse, S., Ogiwara, K., Takano, N., Moriyama, A. and Takahashi, T. (2005). "Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins". FEBS Lett. 579: 6879–6884. doi:10.1016/j.febslet.2005.11.039. PMID 16337200.
↑ Kishi, T., Cloutier, S.M., Kündig, C., Deperthes, D. and Diamandis, E.P. (2006). "Activation and enzymatic characterization of recombinant human kallikrein 8". Biol. Chem. 387: 723–731. doi:10.1515/BC.2006.091. PMID 16800733.

External links

Kallikrein 8 at the US National Library of Medicine Medical Subject Headings (MeSH)

Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)

Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic

Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator

Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase

Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin

Venombin	Ancrod Batroxobin

Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin Streptokinase S1P Cathepsin A G

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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