Karst Hoogsteen

Karst Hoogsteen (October 1, 1923 – August 10, 2015)[1] was a Dutch-born American biochemist famous for noting a new base pairing form in DNA, now called Hoogsteen base pairs.[2] These base pairing intercede in the Watson-Crick base pairing, forging a base pair 'triplex'. The Base Pairs use the N7 Nitrogen as the accepter rather than the N1 as observed in Watson-Crick base pairing. This leads to a twisted, non-linear arrangement.

References

  1. ↑ "Obituary for Dr. Karst Hoogsteen".
  2. ↑ Honig, Barry; Rohs, Remo (24 February 2011), "Biophysics: Flipping Watson and Crick", Nature 470: 472–473, doi:10.1038/470472a.


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