FERMT2

Fermitin family member 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LGX, 2LKO, 2MSU, 4F7H
Identifiers
Symbols	FERMT2 ; KIND2; MIG2; PLEKHC1; UNC112; UNC112B; mig-2
External IDs	OMIM: 607746 MGI: 2385001 HomoloGene: 4976 GeneCards: FERMT2 Gene
Gene ontology Molecular function • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding Cellular component • stress fiber • nucleus • nucleoplasm • cytoplasm • cytosol • focal adhesion • cell cortex • cell surface • extrinsic component of cytoplasmic side of plasma membrane • lamellipodium membrane • I band • filamentous actin Biological process • cell-matrix adhesion • transforming growth factor beta receptor signaling pathway • integrin-mediated signaling pathway • regulation of cell shape • Wnt signaling pathway • integrin activation • cell junction assembly • substrate adhesion-dependent cell spreading • focal adhesion assembly • protein localization to membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10979	218952
Ensembl	ENSG00000073712	ENSMUSG00000037712
UniProt	Q96AC1	Q8CIB5
RefSeq (mRNA)	NM_001134999	NM_146054
RefSeq (protein)	NP_001128471	NP_666166
Location (UCSC)	Chr 14: 52.86 – 52.95 Mb	Chr 14: 45.46 – 45.53 Mb
PubMed search

Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) is a protein that in humans is encoded by the FERMT2 gene.^[1][2][3]

Function

FERMT2 is a component of extracellular matrix structures in mammalian cells and is required for proper control of cell shape change.^[4]

Interactions

FERMT2 has been shown to interact with FBLIM1.^[4]

References

1. Wick M, Bürger C, Brüsselbach S, Lucibello FC, Müller R (January 1994). "Identification of serum-inducible genes: different patterns of gene regulation during G0-->S and G1-->S progression". J. Cell. Sci. 107 (1): 227–39. PMID 8175911.
2. Weinstein EJ, Bourner M, Head R, Zakeri H, Bauer C, Mazzarella R (April 2003). "URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas". Biochim. Biophys. Acta 1637 (3): 207–16. doi:10.1016/S0925-4439(03)00035-8. PMID 12697302.
3. "Entrez Gene: FERMT2".
4. Tu Y, Wu S, Shi X, Chen K, Wu C (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. PMID 12679033.

External links

• FERMT2 Info with links in the Cell Migration Gateway

Further reading

• Tu Y, Wu S, Shi X, Chen K, Wu C (2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. PMID 12679033.
• Siegel DH, Ashton GH, Penagos HG, Lee JV, Feiler HS, Wilhelmsen KC, South AP, Smith FJ, Prescott AR, Wessagowit V, Oyama N, Akiyama M, Al Aboud D, Al Aboud K, Al Githami A, Al Hawsawi K, Al Ismaily A, Al-Suwaid R, Atherton DJ, Caputo R, Fine JD, Frieden IJ, Fuchs E, Haber RM, Harada T, Kitajima Y, Mallory SB, Ogawa H, Sahin S, Shimizu H, Suga Y, Tadini G, Tsuchiya K, Wiebe CB, Wojnarowska F, Zaghloul AB, Hamada T, Mallipeddi R, Eady RA, McLean WH, McGrath JA, Epstein EH (2003). "Loss of Kindlin-1, a Human Homolog of the Caenorhabditis elegans Actin–Extracellular-Matrix Linker Protein UNC-112, Causes Kindler Syndrome". Am. J. Hum. Genet. 73 (1): 174–87. doi:10.1086/376609. PMC 1180579. PMID 12789646.
• Kato K, Shiozawa T, Mitsushita J, Toda A, Horiuchi A, Nikaido T, Fujii S, Konishi I (2004). "Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas". Hum. Pathol. 35 (1): 55–60. doi:10.1016/j.humpath.2003.08.019. PMID 14745725.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.