Krüppel

Krüppel is a gap gene originally described in Drosophila melanogaster, which encodes a zinc finger transcription factor with four tandemly repeated zinc finger domains.^[1]

Krüppel means, literally, "cripple" in German, named for the crippled appearance of mutant larva. Krüppel regulates the expression of several other gap genes.^[2]

See also Kruppel-like factors which have been recently investigated in the heart but are well characterized for their role in carcinogenesis.

References

External links

Diagram at Davidson College - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Krüppel (in blue) Hairy (green) and Giant (red).
Kruppel protein, Drosophila at the US National Library of Medicine Medical Subject Headings (MeSH)

This article is issued from Wikipedia - version of the Wednesday, July 31, 2013. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.