Kynapcin

Skeletal formula of kynapcin-24

Kynapcin is a general name for a number of dibenzofuranyl derivatives of the molecule polyozellin, present in the fungus Polyozellus multiplex. Like polyozellin, it inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.[1] Several kynapcins have been found in P. multiplex, each with different chemical properties, including kynapcin-12,[2] kynapcin-13 and -28,[3] and -24.[4] A total synthesis of kynapcin-24 was achieved in 2009.[5]

References

  1. ↑ Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID. (1997). "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics 50 (9): 773–77. doi:10.7164/antibiotics.50.773. PMID 9360624.
  2. ↑ Lee HJ, Rhee IK, Lee KB, Yoo ID, Song KS. (2000). "Kynapcin-12, a new p-terphenyl derivative from Polyozellus multiplex, inhibits prolyl endopeptidase". The Journal of Antibiotics 53 (7): 714–19. doi:10.7164/antibiotics.53.714. PMID 10994814.
  3. ↑ Kim SI, Park IH, Song KS. (2002). "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex". The Journal of Antibiotics 55 (7): 623–28. doi:10.7164/antibiotics.55.623. PMID 12243451.
  4. ↑ Song KS, Raskin I. (2002). "A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex". Journal of Natural Products 65 (1): 76–78. doi:10.1021/np010194b. PMID 11809072.
  5. ↑ Yang LY, Chang CF, Huang YC, Lee YJ, Hu CC, Tseng TH. (2009). "The first total synthesis of kynapcin-24 by palladium catalysis". Synthesis-Stuttgart 7: 1175–79. doi:10.1055/s-0028-1087998.


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