L-amino-acid dehydrogenase

L-amino-acid dehydrogenase
Identifiers
EC number	1.4.1.5
CAS number	9029-13-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a L-amino-acid dehydrogenase (EC 1.4.1.5) is an enzyme that catalyzes the chemical reaction

an L-amino acid + H₂O + NAD⁺ $\rightleftharpoons$ a 2-oxo acid + NH₃ + NADH + H⁺

The 3 substrates of this enzyme are L-amino acid, H₂O, and NAD⁺, whereas its 4 products are 2-oxo acid, NH₃, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-amino-acid:NAD+ oxidoreductase (deaminating).

References

• Nisman, B; Mager, J (9 February 1952). "Diphosphopyridine nucleotide and phosphate requirement for oxidation of amino-acids by cell-free extracts of obligate anaerobes". Nature 169: 243–244. doi:10.1038/169243a0.