L-ascorbate—cytochrome-b5 reductase

L-ascorbate—cytochrome-b5 reductase
Identifiers
EC number	1.10.2.1
CAS number	37237-57-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a L-ascorbate—cytochrome-b₅ reductase (EC 1.10.2.1) is an enzyme that catalyzes the chemical reaction

L-ascorbate + ferricytochrome b₅ $\rightleftharpoons$ monodehydroascorbate + ferrocytochrome b₅ + H⁺

Thus, the two substrates of this enzyme are L-ascorbate and ferricytochrome b₅, whereas its 3 products are monodehydroascorbate, ferrocytochrome b₅, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with a cytochrome as acceptor. The systematic name of this enzyme class is L-ascorbate:ferricytochrome-b₅ oxidoreductase. This enzyme is also called ascorbate-cytochrome b₅ reductase.

References

• Everling FB, Weis W, Staudinger H (1969). "[Kinetic studies on an ascorbate: ferricytochrome b5 oxidoreductase (EC 1.1.2.?)]". Hoppe. Seylers. Z. Physiol. Chem. 350 (12): 1485–92. PMID 5363650.