L3MBTL

L(3)mbt-like 1 (Drosophila)
PDB rendering based on 1oyx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1OYX​, 1OZ2​, 1OZ3​, 2PQW​, 2RHI​, 2RHU​, 2RHX​, 2RHY​, 2RHZ​, 2RI2​, 2RI3​, 2RI5​, 2RJC​, 2RJD​, 2RJE​, 2RJF​, 3OQ5​, 3P8H​, 3UWN​
Identifiers
Symbols	L3MBTL1 ; H-L(3)MBT; L3MBTL; ZC2HC3; dJ138B7.3
External IDs	OMIM: 608802 MGI: 2676663 HomoloGene: 41846 ChEMBL: 1287622 GeneCards: L3MBTL1 Gene
Gene ontology Molecular function • chromatin binding • transcription factor activity, sequence-specific DNA binding • protein binding • zinc ion binding • nucleosome binding • nucleosomal histone binding • SAM domain binding • methylated histone binding • histone binding • identical protein binding Cellular component • chromatin • condensed chromosome • nucleus • nucleoplasm • nucleolus • plasma membrane Biological process • transcription, DNA-templated • regulation of mitotic nuclear division • chromatin modification • hemopoiesis • regulation of megakaryocyte differentiation • negative regulation of transcription, DNA-templated • regulation of cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26013	241764
Ensembl	ENSG00000185513	ENSMUSG00000035576
UniProt	Q9Y468	A2A5N8
RefSeq (mRNA)	NM_015478	NM_001081338
RefSeq (protein)	NP_056293	NP_001074807
Location (UCSC)	Chr 20: 43.51 – 43.55 Mb	Chr 2: 162.94 – 162.97 Mb
PubMed search

Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.^[1][2][3]

This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.^[3]

References

1. Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H (Sep 1999). "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes". Oncogene 18 (26): 3799–809. doi:10.1038/sj.onc.1202732. PMID 10445843.
2. Trojer P, Li G, Sims RJ 3rd, Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D (Jun 2007). "L3MBTL1, a histone-methylation-dependent chromatin lock". Cell 129 (5): 915–28. doi:10.1016/j.cell.2007.03.048. PMID 17540172.
3. "Entrez Gene: L3MBTL l(3)mbt-like (Drosophila)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• MacGrogan D, Kalakonda N, Alvarez S, et al. (2004). "Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells". Genes Chromosomes Cancer 41 (3): 203–13. doi:10.1002/gcc.20087. PMID 15334543.
• Li J, Bench AJ, Vassiliou GS, et al. (2004). "Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies". Proc. Natl. Acad. Sci. U.S.A. 101 (19): 7341–6. doi:10.1073/pnas.0308195101. PMC 409920. PMID 15123827.
• Wang WK, Tereshko V, Boccuni P, et al. (2004). "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets". Structure 11 (7): 775–89. doi:10.1016/S0969-2126(03)00127-8. PMID 12842041.
• Boccuni P, MacGrogan D, Scandura JM, Nimer SD (2003). "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)". J. Biol. Chem. 278 (17): 15412–20. doi:10.1074/jbc.M300592200. PMID 12588862.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.