L3MBTL2

L(3)mbt-like 2 (Drosophila)

Rendering based on PDB 2W0T.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols L3MBTL2 ; H-l(3)mbt-l; L3MBT
External IDs OMIM: 611865 MGI: 2443584 HomoloGene: 12882 GeneCards: L3MBTL2 Gene
Orthologs
Species Human Mouse
Entrez 83746 214669
Ensembl ENSG00000100395 ENSMUSG00000022394
UniProt Q969R5 P59178
RefSeq (mRNA) NM_001003689 NM_001289711
RefSeq (protein) NP_113676 NP_001276640
Location (UCSC) Chr 22:
41.21 – 41.23 Mb
Chr 15:
81.66 – 81.69 Mb
PubMed search

Lethal(3)malignant brain tumor-like 2 protein is a protein that in humans is encoded by the L3MBTL2 gene.[1][2]

Model organisms

Model organisms have been used in the study of L3MBTL2 function. A conditional knockout mouse line called L3mbtl2tm2a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]

References

  1. Wismar J (Oct 2001). "Molecular characterization of h-l(3)mbt-like: a new member of the human mbt family". FEBS Letters 507 (1): 119–21. doi:10.1016/S0014-5793(01)02959-3. PMID 11682070.
  2. "Entrez Gene: L3MBTL2 l(3)mbt-like 2 (Drosophila)".
  3. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  4. 1 2 "International Mouse Phenotyping Consortium".
  5. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  6. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  7. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  8. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  9. 1 2 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading


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